Intravascular Large B-cell Lymphoma Mimicking Hepatobiliary Infection: A Case Report and Literature Review

• Published in: Internal Medicine Vol. 58; no. 13; pp. 1885 - 1889
• Main Authors: Kusunoki, Ryusaku, Fujishiro, Hirofumi, Yoshimura, Misaki, Sawada, Kiyoka, Suemitsu, Shinsuke, Kataoka, Masatoshi, Fujiwara, Aya, Tsukano, Kousuke, Kotani, Satoshi, Yamanouchi, Satoshi, Tanaka, Masaki, Miyaoka, Youichi, Miyake, Tatsuya, Kohge, Naruaki, Imaoka, Tomonori, Ohnuma, Hideyuki, Ishihara, Shunji, Kinoshita, Yoshikazu
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Society of Internal Medicine 01.07.2019; Japan Science and Technology Agency
• Subjects: acalculous cholecystitis; Antibiotics; Autopsies; Autopsy; B-cell lymphoma; Case Report; Cholecystitis; Fever; Gallbladder; Gallbladder diseases; Infections; Internal medicine; intravascular large B-cell lymphoma; Literature reviews; Lymphocytes B; Lymphoma; Mimicry; Pain; acalculous cholecystitis; intravascular large B-cell lymphoma
• ISSN: 0918-2918; 1349-7235
• DOI: 10.2169/internalmedicine.1995-18

Intravascular large B-cell lymphoma (IVLBCL) frequently involves the hepatobiliary system, but its clinical course and pathophysiology are still not fully known. We herein describe a case of IVLBCL mimicking acute hepatobiliary infection. An 85-year-old woman was admitted because of fever and epigastric pain, and she was diagnosed to have acute acalculous cholecystitis based on gallbladder wall thickening with fluid collection. The gallbladder swelling regressed within several days, and areas of intrahepatic hypoperfusion appeared. Inflammation continued despite treatment with antibiotics, and she died within 21 days. An autopsy examination revealed IVLBCL. IVLBCL can present as acute cholecystitis with an improvement in the imaging findings and the presence of a subsequent liver mass.