CD2 is a surface marker for mouse and rat spermatogonial stem cells

• Published in: Journal of Reproduction and Development Vol. 66; no. 4; pp. 341 - 349
• Main Authors: KANATSU-SHINOHARA, Mito, CHEN, Guiying, MORIMOTO, Hiroko, SHINOHARA, Takashi
• Format: Journal Article
• Language: English
• Published: Japan The Society for Reproduction and Development 2020; Japan Science and Technology Agency
• Subjects: Aging; Apoptosis; CD2; Flow cytometry; Original; Spermatogonial stem cells; Stem cell transplantation; Stem cells; Surface markers; Testes; Transplantation; CD2; Spermatogonial stem cells; Transplantation

The spermatogonial stem cell (SSC) population in testis is small, and the lack of SSC markers has severely handicapped research on these cells. During our attempt to identify genes involved in SSC aging, we found that CD2 is expressed in cultured SSCs. Flow cytometric analysis and spermatogonial tra...