A 14-Membered Macrolide and Isocoumarin Derivatives from the Cultured Lichen Mycobionts of Graphis vestitoides

Spore-derived mycobionts of the crustose lichen Graphis vestitoides collected in Vietnam were cultivated on a malt-yeast extract medium supplemented with 10% sucrose. The investigation of their metabolites resulted in isolation of a novel 14-membered macrolide and a new isocoumarin, together with fi...

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Bibliographic Details
Published inChemical & pharmaceutical bulletin Vol. 61; no. 3; pp. 358 - 362
Main Authors Le, Duy Hoang, Takenaka, Yukiko, Hamada, Nobuo, Miyawaki, Hiromi, Tanahashi, Takao
Format Journal Article
LanguageEnglish
Published TOKYO The Pharmaceutical Society of Japan 2013
Pharmaceutical Society of Japan
Pharmaceutical Soc Japan
Japan Science and Technology Agency
Subjects
14-membered macrolide
Chemistry
Chemistry, Medicinal
Chemistry, Multidisciplinary
Graphis
Graphis vestitoides
isocoumarin
Isocoumarins - chemistry
lichen
Lichens - chemistry
Life Sciences & Biomedicine
Macrolides - chemistry
mycobiont
Pharmacology & Pharmacy
Physical Sciences
Science & Technology
Spectrum Analysis - methods
Vietnam
Vietnam
14-membered macrolide
ABSOLUTE-CONFIGURATION
SCRIPTA
lichen
isocoumarin
Graphis vestitoides
mycobiont
METABOLITE
SP
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Summary:Spore-derived mycobionts of the crustose lichen Graphis vestitoides collected in Vietnam were cultivated on a malt-yeast extract medium supplemented with 10% sucrose. The investigation of their metabolites resulted in isolation of a novel 14-membered macrolide and a new isocoumarin, together with five known isocoumarin derivatives. Their structures were determined by spectroscopic and chemical means. This is the first instance of isolation of a 14-membered macrolide from a lichen mycobiont.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.c12-00853