Protection of human intestinal epithelial cells from oxidative stress caused by mercury using lactic acid bacteria

Heavy metals are harmful to human health. Therefore, we investigated the biosorption of heavy metals by lactic acid bacteria (LAB). Of all the tested heavy metals, biosorption by LAB was highest for mercury, followed by lead, cadmium, and finally arsenic. The viability of HCT-116 cells was reduced b...

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Bibliographic Details
Published inBioscience of Microbiota, Food and Health Vol. 39; no. 3; pp. 183 - 187
Main Authors KINOSHITA, Hideki, JUMONJI, Mai, YASUDA, Shin, IGOSHI, Keiji
Format Journal Article
LanguageEnglish
Japanese
Published Tokyo BMFH Press 01.01.2020
Japan Science and Technology Agency
Subjects
antioxidant enzyme
Antioxidants
Arsenic
Bacteria
Biosorption
Cadmium
Catalase
Detoxification
Enzymatic activity
Epithelial cells
Glutathione
Glutathione peroxidase
heavy metal
Heavy metals
Intestine
Lactic acid
Lactic acid bacteria
Mercury
Mercury (metal)
Oxidative stress
Peroxidase
Superoxide dismutase
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Summary:Heavy metals are harmful to human health. Therefore, we investigated the biosorption of heavy metals by lactic acid bacteria (LAB). Of all the tested heavy metals, biosorption by LAB was highest for mercury, followed by lead, cadmium, and finally arsenic. The viability of HCT-116 cells was reduced by half in the presence of 7.5 µg/mL mercury but recovered after the addition of selected LAB strains. HCT-116 cells showed increased superoxide dismutase and catalase activities, whereas glutathione peroxidase activities decreased significantly. Addition of Lactobacillus sakei TOKAI 57m recovered all antioxidant enzyme activities. Our results suggest that this strain can be used for cellular detoxification.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:2186-6953
2186-3342
2186-3342
DOI:10.12938/bmfh.2019-049