Hantavirus RNA in saliva from patients with hemorrhagic fever with renal syndrome

Hantaviruses cause 2 zoonotic diseases, hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome. Infection is usually initiated after inhalation of virus-contaminated rodent excreta. In addition to the zoonotic infection route, growing evidence suggests person-to-person...

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Published inEmerging infectious diseases Vol. 14; no. 3; pp. 406 - 411
Main Authors Pettersson, Lisa, Klingström, Jonas, Hardestam, Jonas, Lundkvist, Ake, Ahlm, Clas, Evander, Magnus
Format Journal Article
LanguageEnglish
Published United States U.S. National Center for Infectious Diseases 01.03.2008
Centers for Disease Control and Prevention
Subjects
Adult
Aged
Antibodies, Viral - blood
Base Sequence
Disease transmission
Female
Hantavirus
HCPS
Health aspects
Hemorrhagic Fever with Renal Syndrome - virology
HFRS
Humans
Immunoglobulin G - blood
Immunoglobulin M - blood
Infection
Male
Medicin och hälsovetenskap
Middle Aged
Puumala virus
RNA
RNA, Viral - analysis
RNA, Viral - blood
RNA, Viral - genetics
saliva
Saliva - chemistry
Saliva - virology
transmission
Sweden
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Summary:Hantaviruses cause 2 zoonotic diseases, hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome. Infection is usually initiated after inhalation of virus-contaminated rodent excreta. In addition to the zoonotic infection route, growing evidence suggests person-to-person transmission of Andes virus. For this reason, we studied whether saliva from HFRS patients contained hantavirus. During an outbreak in northern Sweden of nephropathia epidemica (NE), a milder form of hemorrhagic fever with renal syndrome, we collected saliva and plasma from 14 hospitalized NE patients with verified Puumala virus (PUUV) infection. PUUV RNA was detected in saliva from 10 patients (range 1,530-121,323 PUUV RNA copies/mL) by quantitative reverse transcription-PCR. The PUUV S-segment sequences from saliva and plasma of the same patients were identical. Our data show that hantavirus RNA could be detected in human saliva several days after onset of disease symptoms and raise the question whether interhuman transmission of hantavirus may occur through saliva.
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ISSN:1080-6040
1080-6059
1080-6059
DOI:10.3201/eid1403.071242