Spontaneous Iron Accumulation in Hepatocytes of a 7-Week-Old Female Rat

Spontaneous iron accumulation in hepatocytes was observed in a 7-week-old female Han Wistar GALAS rat. Very fine yellowish brown pigments, which showed a positive reaction with Berlin Blue stain, were apparent in the cytoplasm close to the bile canaliculi, with a diminishing periportal-to-centrilobu...

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Published inJournal of Toxicologic Pathology Vol. 22; no. 3; pp. 199 - 203
Main Authors Miyata, Kaori, Sukata, Tokuo, Kushida, Masahiko, Ogata, Keiko, Suzuki, Manabu, Ozaki, Masakazu, Ozaki, Keisuke, Uwagawa, Satoshi
Format Journal Article
LanguageEnglish
Published Japan JAPANESE SOCIETY OF TOXICOLOGIC PATHOLOGY 01.01.2009
Japan Science and Technology Agency
The Japanese Society of Toxicologic Pathology
Subjects
Case Report
hepatocyte
iron accumulation
iron overload
rats
spontaneous
iron overload
hepatocyte
rats
iron accumulation
spontaneous
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Summary:Spontaneous iron accumulation in hepatocytes was observed in a 7-week-old female Han Wistar GALAS rat. Very fine yellowish brown pigments, which showed a positive reaction with Berlin Blue stain, were apparent in the cytoplasm close to the bile canaliculi, with a diminishing periportal-to-centrilobular gradient. There were also differences in distribution between and within lobes. Transmission electron microscopy revealed cytosolic ferritin and pericanalicular siderosomes in hepatocytes. No degeneration or necrotic changes were observed, and non-hepatocyte cells did not demonstrate any obvious accumulation of iron. There were no abnormalities in the animal other than this finding in the liver.
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ISSN:0914-9198
1881-915X
1347-7404
DOI:10.1293/tox.22.199