SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness
A vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is needed to control the coronavirus disease 2019 (COVID-19) global pandemic. Structural studies have led to the development of mutations that stabilize Betacoronavirus spike proteins in the prefusion state, improving their e...
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Published in | Nature (London) Vol. 586; no. 7830; pp. 567 - 571 |
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Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
London
Nature Publishing Group UK
22.10.2020
Nature Publishing Group |
Subjects | |
Online Access | Get full text |
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Summary: | A vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is needed to control the coronavirus disease 2019 (COVID-19) global pandemic. Structural studies have led to the development of mutations that stabilize
Betacoronavirus
spike proteins in the prefusion state, improving their expression and increasing immunogenicity
1
. This principle has been applied to design mRNA-1273, an mRNA vaccine that encodes a SARS-CoV-2 spike protein that is stabilized in the prefusion conformation. Here we show that mRNA-1273 induces potent neutralizing antibody responses to both wild-type (D614) and D614G mutant
2
SARS-CoV-2 as well as CD8
+
T cell responses, and protects against SARS-CoV-2 infection in the lungs and noses of mice without evidence of immunopathology. mRNA-1273 is currently in a phase III trial to evaluate its efficacy.
mRNA-1273, an mRNA vaccine that encodes a stabilized prefusion-state severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein, elicits robust immune responses and protects mice against replication of SARS-CoV-2 in the upper and lower airways. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Authors have equal contribution to this study K.S.C., D.K.E., S.R.L., O.M.A, S.B.B., R.A.G., S.H., A.S., C.Z., A.T.D., K.H.D., S.E., C.A.S., A.W., E.J.F., D.R.M, K.W.B., M.M., B.M.N., G.B.H., K.W., C.H., K.B., D.G.D., L.M., I.R., W.P.K, S.S., L.W., Y.Z., J.C., L.S., L.A.C., E.P., R.J.L., N.E.A., E.N., M.M., V.P., C.L., M.K.L., W.S., K.G., K.L., E.S.Y., A.W., G.A., N.A.D.R., G.S.J., H.B., G.S.A., M.N., T.J.R., M.R.D., I.N.M., K.M.M., J.R.M., R.S.B., A.C., and B.S.G. designed, completed, and/or analyzed experiments. K.S.C., O.M.A., G.B.H., N.W., D.W., J.S.M., and B.S.G. contributed new reagents/analytic tools. K.S.C., K.M.M, and B.S.G. wrote the manuscript. All authors contributed to discussions in regard to and editing of the manuscript. Author Contributions |
ISSN: | 0028-0836 1476-4687 |
DOI: | 10.1038/s41586-020-2622-0 |