Hypotensive Activity and Toxicology of Constituents from Bombax ceiba Stem Bark

A novel constituent, shamimicin, 1′′′, 1′′′′′′′-bis-2-(3,4-dihydroxyphenyl)-3,4-dihydro-3,7-dihydroxy-5-O-xylopyranosyloxy-2H-1-benzopyran alongwith lupeol, which possesses potent hypotensive activity has been isolated from Bombax ceiba stem bark. BCBMM—one of the most active hypotensive fractions h...

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Bibliographic Details
Published inBiological & Pharmaceutical Bulletin Vol. 26; no. 1; pp. 41 - 46
Main Authors Saleem, Rubeena, Ahmad, Syed Iqbal, Ahmed, Mohammad, Faizi, Zareen, Zikr-ur-Rehman, Sadia, Ali, Muhammad, Faizi, Shaheen
Format Journal Article
LanguageEnglish
Published Tokyo The Pharmaceutical Society of Japan 2003
Pharmaceutical Society of Japan
Maruzen
Japan Science and Technology Agency
Subjects
Animals
Biological and medical sciences
Bombax - toxicity
Bombax ceiba
Female
histopathology
Hypotension - chemically induced
Hypotension - pathology
hypotensive activity
Male
Medical sciences
Mice
novel benzopyran
Plant Bark - toxicity
Plant Extracts - administration & dosage
Plant Extracts - toxicity
Plant Stems - toxicity
Rats
Rats, Sprague-Dawley
histopathology
novel benzopyran
hypotensive activity
Bombax ceiba
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Summary:A novel constituent, shamimicin, 1′′′, 1′′′′′′′-bis-2-(3,4-dihydroxyphenyl)-3,4-dihydro-3,7-dihydroxy-5-O-xylopyranosyloxy-2H-1-benzopyran alongwith lupeol, which possesses potent hypotensive activity has been isolated from Bombax ceiba stem bark. BCBMM—one of the most active hypotensive fractions has revealed its adverse effects on heart, liver and kidneys of mice at the dose of 1000 mg/kg/d.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.26.41