Usefulness of the octreotide test in Japanese patients for predicting the presence/absence of somatostatin receptor 2 expression in insulinomas

• Published in: ENDOCRINE JOURNAL Vol. 63; no. 2; pp. 135 - 142
• Main Authors: Nakamura, Akinobu, Mitsuhashi, Tomoko, Takano, Yoshinari, Miyoshi, Hideaki, Kameda, Hiraku, Nomoto, Hiroshi, Nagai, So, Hatanaka, Yutaka, Shimizu, Chikara, Terauchi, Yasuo, Atsumi, Tatsuya
• Format: Journal Article
• Language: English; Japanese
• Published: Japan The Japan Endocrine Society 2016
• Subjects: Adult; Aged; Aged, 80 and over; Diagnostic Techniques, Endocrine; Female; Gene Expression Regulation, Neoplastic - drug effects; Glucose Tolerance Test; Humans; Insulinoma; Insulinoma - diagnosis; Insulinoma - drug therapy; Insulinoma - metabolism; Japan; Male; Middle Aged; Octreotide; Octreotide - pharmacology; Octreotide - therapeutic use; Pancreatic Neoplasms - diagnosis; Pancreatic Neoplasms - drug therapy; Pancreatic Neoplasms - metabolism; Predictive Value of Tests; Prognosis; Receptors, Somatostatin - metabolism; Somatostatin receptor
• ISSN: 0918-8959; 1348-4540
• DOI: 10.1507/endocrj.EJ15-0371

We investigated the relationship between the results of the octreotide test and somatostatin receptor (SSTR) 2 expression in insulinoma patients, to evaluate the usefulness of this test for predicting SSTR2 expression in insulinomas in Japanese patients. Five females and one male were included in the study. All patients underwent the octreotide test before the surgery carried out to resect the tumor, and histopathological examination of the resected tumor was performed by a single experienced pathologist. SSTR2 expression was evaluated by the SSTR2 immunohistochemistry scoring system. Insulinoma was clinically diagnosed and surgically resected in all six patients. In the octreotide test, suppression of insulin secretion was sufficient after loading in patients 1-4 and 6. In patient 5, however, the suppression of insulin secretion was insufficient, which resulted in severe hypoglycemia with endogenous relative hyperinsulinemia after the octreotide loading. The histopathological findings revealed SSTR2 expression in the insulinomas of patients 1-4 and 6, but not in the insulinoma of patient 5. In conclusion, improvement of hyperinsulinemic hypoglycemia by octreotide in Japanese insulinoma patients was associated with SSTR2 expression in the tumor. Our results suggest that the octreotide test could be useful for predicting SSTR2 expression in the tumor.