A prospective study of trans fat intake and risk of preeclampsia in Denmark

• Published in: European journal of clinical nutrition Vol. 65; no. 8; pp. 944 - 951
• Main Authors: Chavarro, J E, Halldorsson, T I, Leth, T, Bysted, A, Olsen, S F
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.08.2011; Nature Publishing Group
• Subjects: 631/45/287/1182; 692/699/75/243/793; 692/700/478/174; Adult; Biological and medical sciences; Biomarkers; Clinical Nutrition; confidence interval; Confidence intervals; Denmark; Denmark - epidemiology; Diet; Dietary Fats - administration & dosage; Dietary Fats - adverse effects; Diseases of mother, fetus and pregnancy; Epidemiology; fat intake; Fats; Feeding. Feeding behavior; Female; Food; food availability; food frequency questionnaires; Food Supply; Fundamental and applied biological sciences. Psychology; Gynecology. Andrology. Obstetrics; Health aspects; Humans; Internal Medicine; Interviews as Topic; Logistic Models; Maternal Nutritional Physiological Phenomena; Medical sciences; Medicine; Medicine & Public Health; Metabolic Diseases; Multivariate Analysis; Nutrition Assessment; Oils & fats; original-article; patients; Pre-eclampsia; Pre-Eclampsia - epidemiology; Pre-Eclampsia - etiology; Preeclampsia; Pregnancy; Pregnancy. Fetus. Placenta; Prospective Studies; Public Health; Reduction; relative risk; Risk; Risk Factors; Surveys and Questionnaires; Trans fats; Trans fatty acids; Trans Fatty Acids - administration & dosage; Trans Fatty Acids - adverse effects; Vertebrates: anatomy and physiology, studies on body, several organs or systems; women; Young Adult; Denmark; Europe; fat; Denmark; preeclampsia; diet; Consumption; Pregnancy disorders; Metabolic diseases; Risk; Pregnancy toxemia; Feeding; Prospective; Diet; Preeclampsia; Trans stereoisomer; Risk factor; Fat; trans fat
• ISSN: 0954-3007; 1476-5640; 1476-5640
• DOI: 10.1038/ejcn.2011.66

Background/Objectives: An association between biomarkers of trans fat intake and greater risk of preeclampsia has been reported, but research in this area is scant. Thus, we examined the association of second trimester intake of trans fats with risk of preeclampsia and severe preeclampsia. Subjects/Methods: We followed 67 186 pregnancies of women participating in the Danish National Birth Cohort between 1998 and 2003. Diet was assessed with a food frequency questionnaire at gestation week 25, and preeclampsia diagnosis was obtained by linkage with the Danish National Patient Registry. Results: There were 1804 cases of preeclampsia and 402 cases of severe preeclampsia identified in the cohort. Intake of trans fats decreased during the study period as a consequence of a reduction in industrial trans fat intake. Second trimester intake of trans fats was unrelated to risk of preeclampsia or severe preeclampsia. The relative risk (95% confidence interval; P , trend) of preeclampsia and severe preeclampsia comparing top to bottom quintiles of trans fat intake were 0.95(0.81; 1.11, 0.33) and 1.07 (0.78; 1.48, 0.92), respectively. Conclusion: Second trimester intake of trans fats is unrelated to risk of preeclampsia within the intake range observed in a period of gradual reduction of industrial trans fats from the Danish food supply.