Self-Guided Supramolecular Cargo-Loaded Nanomotors with Chemotactic Behavior towards Cells
Delivery vehicles that are able to actively seek and precisely locate targeted tissues using concentration gradients of signaling molecules have hardly been explored. The directed movement toward specific cell types of cargo‐loaded polymeric nanomotors along a hydrogen peroxide concentration gradien...
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Published in | Angewandte Chemie (International ed.) Vol. 54; no. 40; pp. 11662 - 11665 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Weinheim
WILEY-VCH Verlag
28.09.2015
WILEY‐VCH Verlag Wiley Subscription Services, Inc |
Edition | International ed. in English |
Subjects | |
Online Access | Get full text |
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Summary: | Delivery vehicles that are able to actively seek and precisely locate targeted tissues using concentration gradients of signaling molecules have hardly been explored. The directed movement toward specific cell types of cargo‐loaded polymeric nanomotors along a hydrogen peroxide concentration gradient (chemotaxis) is reported. Through self‐assembly, bowl‐shaped poly(ethylene glycol)‐b‐polystyrene nanomotors, or stomatocytes, were formed with platinum nanoparticles entrapped in the cavity while a model drug was encapsulated in the inner compartment. Directional movement of the stomatocytes in the presence of a fuel gradient (chemotaxis) was first demonstrated in both static and dynamic systems using glass channels and a microfluidic flow. The highly efficient response of these motors was subsequently shown by their directional and autonomous movement towards hydrogen peroxide secreting neutrophil cells.
Chemotactic nanoparticles: Platinum‐loaded polystyrene nanoparticles were shown to exhibit directional movement along hydrogen peroxide gradients in both static and flowing systems. Furthermore, the nanoparticles could encapsulate the model cancer drug doxorubicin and migrate towards hydrogen peroxide producing neutrophil cells, suggesting such nanoparticles could be used as drug delivery vehicles. |
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Bibliography: | Funded Access Ministry of Education, Culture and Science - No. 024.001.035 ArticleID:ANIE201504186 China scholarship council European Union - No. FP7/2007-20012; No. ERC-StG 307679 ark:/67375/WNG-LHX2JG59-R istex:1A4B3E918748F0BD07C206F03E1C59F9F7B09FCC ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Supporting information for this article is available on the WWW under http://dx.doi.org/10.1002/anie.201504186. |
ISSN: | 1433-7851 1521-3773 |
DOI: | 10.1002/anie.201504186 |