Proteins, platelets, and blood coagulation at biomaterial interfaces

• Published in: Colloids and surfaces, B, Biointerfaces Vol. 124; pp. 49 - 68
• Main Authors: Xu, Li-Chong, Bauer, James W., Siedlecki, Christopher A.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2014
• Subjects: adhesion; biocompatible materials; Biocompatible Materials - adverse effects; Biological; Biological response; Biomaterials; Biomedical materials; Blood coagulation; Blood Coagulation - drug effects; Blood compatibility; blood platelets; Blood Platelets - physiology; cell adhesion; Coagulation; colloids; engineering; Fibrinogen - chemistry; hematologic tests; Humans; Interrogation; Medical devices; medical equipment; Platelets; proteins; Proteins - chemistry; Surface Properties; Surfaces; Surgical implants; Thrombosis; Surfaces; Blood compatibility; Biological response; Thrombosis; Coagulation; Biomaterials
• ISSN: 0927-7765; 1873-4367; 1873-4367
• DOI: 10.1016/j.colsurfb.2014.09.040

•We highlight the current knowledge in the field of blood–materials interactions.•We highlight the role of surface chemistry, energy and topography in mediating blood–material interactions.•We highlight novel methods for measuring biological responses. Blood coagulation and platelet adhesion remain major impediments to the use of biomaterials in implantable medical devices. There is still significant controversy and question in the field regarding the role that surfaces play in this process. This manuscript addresses this topic area and reports on state of the art in the field. Particular emphasis is placed on the subject of surface engineering and surface measurements that allow for control and observation of surface-mediated biological responses in blood and test solutions. Appropriate use of surface texturing and chemical patterning methodologies allow for reduction of both blood coagulation and platelet adhesion, and new methods of surface interrogation at high resolution allow for measurement of the relevant biological factors.