A Hepatocellular Adenoma in a Diet-induced Obese Mouse
A hepatic nodule was noted in a C57BL/6J mouse with diet-induced obesity at 53 weeks of age. Macroscopically, a protruding yellowish white nodule was observed on the visceral surface of the left lateral lobe. Light microscopy demonstrated clear demarcation from the compressed adjacent parenchyma, wi...
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| Published in | Journal of Toxicologic Pathology Vol. 23; no. 1; pp. 59 - 62 |
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| Language | English |
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Japan
JAPANESE SOCIETY OF TOXICOLOGIC PATHOLOGY
01.01.2010
Japan Science and Technology Agency The Japanese Society of Toxicologic Pathology |
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| Abstract | A hepatic nodule was noted in a C57BL/6J mouse with diet-induced obesity at 53 weeks of age. Macroscopically, a protruding yellowish white nodule was observed on the visceral surface of the left lateral lobe. Light microscopy demonstrated clear demarcation from the compressed adjacent parenchyma, with loss of the distinct lobular pattern. The proliferating cells of the lesion varied in shape and showed cellular atypia and prominent nucleoli along with vacuoles of various sizes. Some of the cells contained various-sized eosinophilic inclusion bodies in their cytoplasm, and electron microscopy revealed the presence of lipid droplets in the rough endoplasmic reticulum. Eosinophilic inclusions were observed as electron dense granular material in the rough endoplasmic reticulum, with one or a few low density central cores. A diagnosis of hepatocellular adenoma was made based on these findings. |
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| AbstractList | A hepatic nodule was noted in a C57BL/6J mouse with diet-induced obesity at 53 weeks of age. Macroscopically, a protruding yellowish white nodule was observed on the visceral surface of the left lateral lobe. Light microscopy demonstrated clear demarcation from the compressed adjacent parenchyma, with loss of the distinct lobular pattern. The proliferating cells of the lesion varied in shape and showed cellular atypia and prominent nucleoli along with vacuoles of various sizes. Some of the cells contained various-sized eosinophilic inclusion bodies in their cytoplasm, and electron microscopy revealed the presence of lipid droplets in the rough endoplasmic reticulum. Eosinophilic inclusions were observed as electron dense granular material in the rough endoplasmic reticulum, with one or a few low density central cores. A diagnosis of hepatocellular adenoma was made based on these findings. A hepatic nodule was noted in a C57BL/6J mouse with diet-induced obesity at 53 weeks of age. Macroscopically, a protruding yellowish white nodule was observed on the visceral surface of the left lateral lobe. Light microscopy demonstrated clear demarcation from the compressed adjacent parenchyma, with loss of the distinct lobular pattern. The proliferating cells of the lesion varied in shape and showed cellular atypia and prominent nucleoli along with vacuoles of various sizes. Some of the cells contained various-sized eosinophilic inclusion bodies in their cytoplasm, and electron microscopy revealed the presence of lipid droplets in the rough endoplasmic reticulum. Eosinophilic inclusions were observed as electron dense granular material in the rough endoplasmic reticulum, with one or a few low density central cores. A diagnosis of hepatocellular adenoma was made based on these findings.A hepatic nodule was noted in a C57BL/6J mouse with diet-induced obesity at 53 weeks of age. Macroscopically, a protruding yellowish white nodule was observed on the visceral surface of the left lateral lobe. Light microscopy demonstrated clear demarcation from the compressed adjacent parenchyma, with loss of the distinct lobular pattern. The proliferating cells of the lesion varied in shape and showed cellular atypia and prominent nucleoli along with vacuoles of various sizes. Some of the cells contained various-sized eosinophilic inclusion bodies in their cytoplasm, and electron microscopy revealed the presence of lipid droplets in the rough endoplasmic reticulum. Eosinophilic inclusions were observed as electron dense granular material in the rough endoplasmic reticulum, with one or a few low density central cores. A diagnosis of hepatocellular adenoma was made based on these findings. A hepatic nodule was noted in a C57BL/6J mouse with diet-induced obesity at 53 weeks of age. Macroscopically, a protruding yellowish white nodule was observed on the visceral surface of the left lateral lobe. Light microscopy demonstrated clear demarcation from the compressed adjacent parenchyma, with loss of the distinct lobular pattern. The proliferating cells of the lesion varied in shape and showed cellular atypia and prominent nucleoli along with vacuoles of various sizes. Some of the cells contained various-sized eosinophilic inclusion bodies in their cytoplasm, and electron microscopy revealed the presence of lipid droplets in the rough endoplasmic reticulum. Eosinophilic inclusions were observed as electron dense granular material in the rough endoplasmic reticulum, with one or a few low density central cores. A diagnosis of hepatocellular adenoma was made based on these findings. |
| Author | Kawai, Kouji Fujiwara, Toshihisa Shinozuka, Junko Sato, Hiroko Tanaka, Masaharu Ide, Mika Kume, Eisuke Sakairi, Tetsuya Sano, Fumiko |
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| References | 7. Ghadially FN. Lipid in endoplasmic reticulum (liposomes). In: Ultrastructural Pathology of the Cell and Matrix Volume 1, 3rd ed. Butterworth-Heinemann Ltd. 1988. 9. Dogan S, Hu X, Zhang Y, Maihle NJ, Grande JP, and Cleary MP. Effects of high-fat diet and/or body weight on mammary tumor leptin and apoptosis signaling pathways in MMTV-TGF-alpha mice. Breast Cancer Res. 9: R91. 2007. 3. Hruban Z, Kirsten WH, and Slesers A. Fine structure of spontaneous hepatic tumors of male C3H/fGs mice. Lab Invest. 15: 576-588. 1966. 2. Horinouchi A, Hayashi S, Ando T, and Nonoyama T. Secondary polycythemia in male B6C3F1 mice with spontaneously occurring hepatocellular carcinomas. Toxicol Pathol. 25: 511-515. 1997. 1. Tschop M and Heiman ML. Rodent obesity models: an overview. Exp Clin Endocrinol Diabetes. 109: 307-319. 2001. 8. Dinkova-Kostova AT, Fahey JW, Jenkins SN, Wehage SL, and Talalay P. Rapid body weight gain increases the risk of UV radiation-induced skin carcinogenesis in SKH-1 hairless mice. Nutr Res. 28: 539-543. 2008. 10. Kritchevsky D and Klurfeld DM. Influence of caloric intake on experimental carcinogenesis: a review. Adv Exp Med Biol. 206: 55-68. 1986. 14. Yakar S, Nunez NP, Pennisi P, Brodt P, Sun H, Fallavollita L, Zhao H, Scavo L, Novosyadlyy R, Kurshan N, Stannard B, East-Palmer J, Smith NC, Perkins SN, Fuchs-Young R, Barrett JC, Hursting SD, and LeRoith D. Increased tumor growth in mice with diet-induced obesity: impact of ovarian hormones. Endocrinology. 147: 5826-5834. 2006. 6. Ghadially FN. Proteinaceous granules and crystalline inclusions in rough endoplasmic reticulum. In: Ultrastructural Pathology of the Cell and Matrix Volume 1, 3rd ed. Butterworth-Heinemann Ltd. 1988. 5. Muzzillo DA, Hoshino M, and Matsuyama M. Ultrastructural cytochemistry of eosinophilic inclusions in the cells of hyperplastic nodules and hepatomas in mouse liver. Acta Pathol Jpn. 41: 806-810. 1991. 12. Wheatley KE, Williams EA, Smith NC, Dillard A, Park EY, Nunez NP, Hursting SD, and Lane MA. Low-carbohydrate diet versus caloric restriction: effects on weight loss, hormones, and colon tumor growth in obese mice. Nutr Cancer. 60: 61-68. 2008. 13. Wolff GL, Morrissey RL, and Chen JJ. Amplified response to phenobarbital promotion of hepatotumorigenesis in obese yellow Avy/A (C3H × VY) F-1 hybrid mice. Carcinogenesis. 7: 1895-1898. 1986. 4. Kakizoe S, Goldfarb S, and Pugh TD. Focal impairment of growth in hepatocellular neoplasms of C57BL/6 mice: a possible explanation for the strain's resistance to hepatocarcinogenesis. Cancer Res. 49: 3985-3989. 1989. 11. Nunez NP, Perkins SN, Smith NC, Berrigan D, Berendes DM, Varticovski L, Barrett JC, and Hursting SD. Obesity accelerates mouse mammary tumor growth in the absence of ovarian hormones. Nutr Cancer. 60: 534-541. 2008. 11 12 13 14 MUZZILLO D A (5) 1991; 41 1 2 3 4 6 7 8 9 10 |
| References_xml | – reference: 11. Nunez NP, Perkins SN, Smith NC, Berrigan D, Berendes DM, Varticovski L, Barrett JC, and Hursting SD. Obesity accelerates mouse mammary tumor growth in the absence of ovarian hormones. Nutr Cancer. 60: 534-541. 2008. – reference: 5. Muzzillo DA, Hoshino M, and Matsuyama M. Ultrastructural cytochemistry of eosinophilic inclusions in the cells of hyperplastic nodules and hepatomas in mouse liver. Acta Pathol Jpn. 41: 806-810. 1991. – reference: 7. Ghadially FN. Lipid in endoplasmic reticulum (liposomes). In: Ultrastructural Pathology of the Cell and Matrix Volume 1, 3rd ed. Butterworth-Heinemann Ltd. 1988. – reference: 12. Wheatley KE, Williams EA, Smith NC, Dillard A, Park EY, Nunez NP, Hursting SD, and Lane MA. Low-carbohydrate diet versus caloric restriction: effects on weight loss, hormones, and colon tumor growth in obese mice. Nutr Cancer. 60: 61-68. 2008. – reference: 3. Hruban Z, Kirsten WH, and Slesers A. Fine structure of spontaneous hepatic tumors of male C3H/fGs mice. Lab Invest. 15: 576-588. 1966. – reference: 6. Ghadially FN. Proteinaceous granules and crystalline inclusions in rough endoplasmic reticulum. In: Ultrastructural Pathology of the Cell and Matrix Volume 1, 3rd ed. Butterworth-Heinemann Ltd. 1988. – reference: 8. Dinkova-Kostova AT, Fahey JW, Jenkins SN, Wehage SL, and Talalay P. Rapid body weight gain increases the risk of UV radiation-induced skin carcinogenesis in SKH-1 hairless mice. Nutr Res. 28: 539-543. 2008. – reference: 4. Kakizoe S, Goldfarb S, and Pugh TD. Focal impairment of growth in hepatocellular neoplasms of C57BL/6 mice: a possible explanation for the strain's resistance to hepatocarcinogenesis. Cancer Res. 49: 3985-3989. 1989. – reference: 13. Wolff GL, Morrissey RL, and Chen JJ. Amplified response to phenobarbital promotion of hepatotumorigenesis in obese yellow Avy/A (C3H × VY) F-1 hybrid mice. Carcinogenesis. 7: 1895-1898. 1986. – reference: 1. Tschop M and Heiman ML. Rodent obesity models: an overview. Exp Clin Endocrinol Diabetes. 109: 307-319. 2001. – reference: 10. Kritchevsky D and Klurfeld DM. Influence of caloric intake on experimental carcinogenesis: a review. Adv Exp Med Biol. 206: 55-68. 1986. – reference: 2. Horinouchi A, Hayashi S, Ando T, and Nonoyama T. Secondary polycythemia in male B6C3F1 mice with spontaneously occurring hepatocellular carcinomas. Toxicol Pathol. 25: 511-515. 1997. – reference: 14. Yakar S, Nunez NP, Pennisi P, Brodt P, Sun H, Fallavollita L, Zhao H, Scavo L, Novosyadlyy R, Kurshan N, Stannard B, East-Palmer J, Smith NC, Perkins SN, Fuchs-Young R, Barrett JC, Hursting SD, and LeRoith D. Increased tumor growth in mice with diet-induced obesity: impact of ovarian hormones. Endocrinology. 147: 5826-5834. 2006. – reference: 9. Dogan S, Hu X, Zhang Y, Maihle NJ, Grande JP, and Cleary MP. Effects of high-fat diet and/or body weight on mammary tumor leptin and apoptosis signaling pathways in MMTV-TGF-alpha mice. Breast Cancer Res. 9: R91. 2007. – ident: 3 – ident: 7 doi: 10.1016/B978-0-407-01571-5.50012-4 – ident: 14 doi: 10.1210/en.2006-0311 – ident: 6 doi: 10.1016/B978-0-407-01571-5.50012-4 – ident: 4 – ident: 10 doi: 10.1007/978-1-4613-1835-4_7 – ident: 2 doi: 10.1177/019262339702500514 – ident: 12 doi: 10.1080/01635580701510150 – ident: 8 doi: 10.1016/j.nutres.2008.05.009 – ident: 1 doi: 10.1055/s-2001-17297 – ident: 11 doi: 10.1080/01635580801966195 – ident: 9 doi: 10.1186/bcr1840 – ident: 13 doi: 10.1093/carcin/7.11.1895 – volume: 41 start-page: 806 issn: 0001-6632 issue: 11 year: 1991 ident: 5 doi: 10.1111/j.1440-1827.1991.tb01622.x |
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| Snippet | A hepatic nodule was noted in a C57BL/6J mouse with diet-induced obesity at 53 weeks of age. Macroscopically, a protruding yellowish white nodule was observed... A hepatic nodule was noted in a C57BL/6J mouse with diet-induced obesity at 53 weeks of age. Macroscopically, a protruding yellowish white nodule was observed... |
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| SubjectTerms | Case Report diet-induced obese mouse Hepatocellular adenoma inclusion body |
| Title | A Hepatocellular Adenoma in a Diet-induced Obese Mouse |
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