A Hepatocellular Adenoma in a Diet-induced Obese Mouse

• Published in: Journal of Toxicologic Pathology Vol. 23; no. 1; pp. 59 - 62
• Main Authors: Kawai, Kouji, Sakairi, Tetsuya, Tanaka, Masaharu, Shinozuka, Junko, Ide, Mika, Sato, Hiroko, Fujiwara, Toshihisa, Sano, Fumiko, Kume, Eisuke
• Format: Journal Article
• Language: English
• Published: Japan JAPANESE SOCIETY OF TOXICOLOGIC PATHOLOGY 01.01.2010; Japan Science and Technology Agency; The Japanese Society of Toxicologic Pathology
• Subjects: Case Report; diet-induced obese mouse; Hepatocellular adenoma; inclusion body; inclusion body; Hepatocellular adenoma; diet-induced obese mouse
• ISSN: 0914-9198; 1881-915X; 1881-915X; 1347-7404
• DOI: 10.1293/tox.23.59

A hepatic nodule was noted in a C57BL/6J mouse with diet-induced obesity at 53 weeks of age. Macroscopically, a protruding yellowish white nodule was observed on the visceral surface of the left lateral lobe. Light microscopy demonstrated clear demarcation from the compressed adjacent parenchyma, with loss of the distinct lobular pattern. The proliferating cells of the lesion varied in shape and showed cellular atypia and prominent nucleoli along with vacuoles of various sizes. Some of the cells contained various-sized eosinophilic inclusion bodies in their cytoplasm, and electron microscopy revealed the presence of lipid droplets in the rough endoplasmic reticulum. Eosinophilic inclusions were observed as electron dense granular material in the rough endoplasmic reticulum, with one or a few low density central cores. A diagnosis of hepatocellular adenoma was made based on these findings.