Differences in Liver Injury and Trophoblastic Mitochondrial Damage in Different Preeclampsia-like Mouse Models

• Published in: Chinese medical journal Vol. 128; no. 12; pp. 1627 - 1635
• Main Authors: Han, Yi-Wei, Yang, Zi, Ding, Xiao-Yan, Yu, Huan
• Format: Journal Article
• Language: English
• Published: China Medknow Publications Pvt Ltd 20.06.2015; Medknow Publications and Media Pvt. Ltd; Lippincott Williams & Wilkins Ovid Technologies; Department of Obstetrics and Gynecology,Peking University Third Hospital,Beijing 100191,China; Medknow Publications & Media Pvt Ltd; Wolters Kluwer
• Subjects: Analysis; Animals; Apoptosis; Cholesterol - blood; Complications and side effects; Disease Models, Animal; Enzymes; Fatty acids; Female; Fetal Weight - physiology; Gene expression; Genetic aspects; Glycoproteins; Gynecology; Hospitals; Hypotheses; Laboratory animals; Lipids; Liver - injuries; Liver diseases; Male; Medical screening; Metabolism; Mice; Mice, Inbred C57BL; Mitochondria; Mitochondrial Diseases - blood; Mitochondrial Diseases - pathology; Mitochondrial DNA; Nitric oxide; Obstetrics; Original; Oxidation; Oxidative stress; Pathogenesis; Physiological aspects; Placenta; Placenta - metabolism; Pre-Eclampsia - blood; Pre-Eclampsia - pathology; Preeclampsia; Pregnancy; Proteins; Risk factors; Transgenic animals; Triglycerides - blood; Trophoblasts - pathology; Womens health; 前期; 子痫; 小鼠模型; 滋养细胞; 线粒体; 肝损伤; 血清甘油三酯; 载脂蛋白C; China; Mitochondria; Trophoblast; Triglyceride; Liver; Preeclampsia

Background：Preeclampsia is a multifactorial disease during pregnancy.Dysregulated lipid metabolism may be related to some preeclampsia.We investigated the relationship between triglycerides （TGs） and liver injury in different preeclampsia-like mouse models and their potential common pathways.Methods...