Regulatory Role of SGT1 in Early R Gene-Mediated Plant Defenses

• Published in: Science (American Association for the Advancement of Science) Vol. 295; no. 5562; pp. 2077 - 2080
• Main Authors: Austin, Mark J., Muskett, Paul, Kahn, Katherine, Feys, Bart J., Jonathan D. G. Jones, Parker, Jane E.
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for the Advancement of Science 15.03.2002; American Association for the Advancement of Science; The American Association for the Advancement of Science
• Subjects: Agronomy. Soil science and plant productions; Amino Acid Motifs; Amino Acid Sequence; Antibodies; Arabidopsis; Arabidopsis - genetics; Arabidopsis - metabolism; Arabidopsis - microbiology; Arabidopsis Proteins - chemistry; Arabidopsis Proteins - genetics; Arabidopsis Proteins - metabolism; Biological and medical sciences; Carrier Proteins - chemistry; Carrier Proteins - genetics; Carrier Proteins - metabolism; Cell Cycle Proteins - chemistry; Cell Cycle Proteins - genetics; Cell Cycle Proteins - metabolism; Cell Death; Disease; Flowers & plants; Fundamental and applied biological sciences. Psychology; Genes; Genes, Plant; Genetic aspects; Genetic mutation; Genetics and breeding of economic plants; Histones; Immune response; Immunity, Innate; Immunology; Inoculation; Land Settlement; Leaves; Literary Devices; Microbial colonization; Molecular aspects; Molecular biology; Molecular Sequence Data; Mutation; Oomycetes - pathogenicity; Oomycetes - physiology; Organic Chemistry; Parasitism; Pathogens; Pest resistance; Plant cells; Plant Diseases; Plant Leaves - microbiology; Plant pathogens; Plant Proteins - genetics; Plant Proteins - physiology; Protein Structure, Tertiary; Proteins; R genes; RAR1 protein; Sequence Alignment; SGT1 protein; Spores, Fungal - physiology; ubiquitin ligase; Varietal selection. Specialized plant breeding, plant breeding aims; Yeast; Yeasts; United States; Pseudomonadales; Plant pathogen; Gene interaction; Phycomycetes; Regulator gene; Genetic determinism; Fungi; Arabidopsis thaliana; Microorganism resistance; Molecular signal; Cruciferae; Ligases; Dicotyledones; Multiple resistance; Angiospermae; Bacteria; Pseudomonadaceae; Peronospora parasitica; Aminoacid sequence; Ubiquitin-protein ligase; Thallophyta; Carbon-nitrogen ligases; Enzyme; Protein; Defense mechanism; Spermatophyta; Mutation; Experimental plant
• ISSN: 0036-8075; 1095-9203
• DOI: 10.1126/science.1067747

Animal SGT1 is a component of Skp1-Cullin-F-box protein (SCF) ubiquitin ligases that target regulatory proteins for degradation. Mutations in one (SGT1b) of two highly homologous Arabidopsis SGT1 genes disable early plant defenses conferred by multiple resistance (R) genes. Loss of SGT1b function in resistance is not compensated for by SGT1a. R genes differ in their requirements for SGT1b and a second resistance signaling gene, RAR1, that was previously implicated as an SGT1 interactor. Moreover, SGT1b and RAR1 contribute additively to RPP5-mediated pathogen recognition. These data imply both operationally distinct and cooperative functions of SGT1 and RAR1 in plant disease resistance.