Ferroptosis, a new form of cell death: opportunities and challenges in cancer

• Published in: Journal of hematology and oncology Vol. 12; no. 1; p. 34
• Main Authors: Mou, Yanhua, Wang, Jun, Wu, Jinchun, He, Dan, Zhang, Chunfang, Duan, Chaojun, Li, Bin
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 29.03.2019; BioMed Central; BMC
• Subjects: Actors; Apoptosis; Autophagy; Biochemistry; Cancer; Cancer cells; Cancer research; Cancer therapies; Cancers; Cell Death; Development and progression; Endoplasmic reticulum; Ferroptosis; Ferroptosis - genetics; Gene expression; Genetic aspects; Hematology; Humans; Lipid peroxidation; Lipids; Medical prognosis; Metabolism; Mitochondria; Nanoparticles; NcRNAs; Neoplasms - genetics; Novels; Oncology; Oxidative stress; P53; Pancreatic cancer; Physiological aspects; Review; Therapeutics; Tumor proteins; Tumorigenesis; China; NcRNAs; Ferroptosis; Autophagy; Cancers; Apoptosis; P53
• ISSN: 1756-8722; 1756-8722
• DOI: 10.1186/s13045-019-0720-y

Ferroptosis is a novel type of cell death with distinct properties and recognizing functions involved in physical conditions or various diseases including cancers. The fast-growing studies of ferroptosis in cancer have boosted a perspective for its usage in cancer therapeutics. Here, we review the current findings of ferroptosis regulation and especially focus on the function of ncRNAs in mediating the process of cell ferroptotic death and on how ferroptosis was in relation to other regulated cell deaths. Aberrant ferroptosis in diverse cancer types and tissues were summarized, and we elaborated recent data about the novel actors of some "conventional" drugs or natural compounds as ferroptosis inducers in cancer. Finally, we deliberate future orientation for ferroptosis in cancer cells and current unsettled issues, which may forward the speed of clinical use of ferroptosis induction in cancer treatment.