Association of UCP2 −866 G A polymorphism with chronic inflammatory diseases

• Published in: Genes and immunity Vol. 10; no. 6; pp. 601 - 605
• Main Authors: Yu, X, Wieczorek, S, Franke, A, Yin, H, Pierer, M, Sina, C, Karlsen, T H, Boberg, K M, Bergquist, A, Kunz, M, Witte, T, Gross, W L, Epplen, J T, Alarcón-Riquelme, M E, Schreiber, S, Ibrahim, S M
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.09.2009; Nature Publishing Group
• Subjects: Alleles; Arthritis, Rheumatoid - epidemiology; Arthritis, Rheumatoid - genetics; Arthritis, Rheumatoid - immunology; Biomedical and Life Sciences; Biomedicine; Cancer Research; Case-Control Studies; Cholangitis; Cholangitis, Sclerosing - epidemiology; Cholangitis, Sclerosing - genetics; Cholangitis, Sclerosing - immunology; Chronic Disease; Chronic diseases; chronic inflammatory diseases; Churg-Strauss syndrome; Churg-Strauss Syndrome - epidemiology; Churg-Strauss Syndrome - genetics; Churg-Strauss Syndrome - immunology; Colitis, Ulcerative - epidemiology; Colitis, Ulcerative - genetics; Colitis, Ulcerative - immunology; Crohn Disease - epidemiology; Crohn Disease - genetics; Crohn Disease - immunology; Crohn's disease; DNA, Mitochondrial - genetics; Gene Expression; Gene polymorphism; Genetic aspects; Genetic polymorphisms; Genotype; Germany - epidemiology; Granulomatosis; Human Genetics; Humans; Immunology; Inflammatory bowel diseases; Inflammatory diseases; Ion Channels - genetics; Lupus Erythematosus, Systemic - epidemiology; Lupus Erythematosus, Systemic - genetics; Lupus Erythematosus, Systemic - immunology; MEDICIN; Medicin och hälsovetenskap; MEDICINE; Meta-Analysis as Topic; Mitochondria; Mitochondrial DNA; Mitochondrial Proteins - genetics; Mitochondrial uncoupling protein 2; Multiple sclerosis; Multiple Sclerosis - epidemiology; Multiple Sclerosis - genetics; Multiple Sclerosis - immunology; Polymorphism; Polymorphism, Single Nucleotide - genetics; Psoriasis; Psoriasis - epidemiology; Psoriasis - genetics; Psoriasis - immunology; Rheumatoid arthritis; Risk Factors; Scandinavian and Nordic Countries - epidemiology; short-communication; Systemic lupus erythematosus; Ulcerative colitis; Uncoupling Protein 2; Germany; uncoupling protein 2; chronic inflammatory diseases; mitochondria
• ISSN: 1466-4879; 1476-5470; 1476-5470
• DOI: 10.1038/gene.2009.29

We reported earlier that two mitochondrial gene polymorphisms, UCP2 –866 G/A (rs659366) and mtDNA nt13708 G/A (rs28359178), are associated with multiple sclerosis (MS). Here we aim to investigate whether these functional polymorphisms contribute to other eight chronic inflammatory diseases, including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), Wegener' granulomatosis (WG), Churg–Strauss syndrome (CSS), Crohn's disease (CD), ulcerative colitis (UC), primary sclerosing cholangitis (PSC) and psoriasis. Compared with individual control panels, the UCP2 –866 G/A polymorphism was associated with RA and SLE, and the mtDNA nt13708 G/A polymorphism with RA. Compared with combined controls, the UCP2 –866 G/A polymorphism was associated with SLE, WG, CD and UC. When all eight disease panels and the original MS panel were combined in a meta-analysis, the UCP2 was associated with chronic inflammatory diseases in terms of either alleles (odds ratio (OR)=0.91, 95% confidence interval (95% CI): 0.86–0.96), P =0.0003) or genotypes (OR=0.88, (95% CI: 0.82–0.95), P =0.0008), with the –866A allele associated with a decreased risk to diseases. As the −866A allele increases gene expression, our findings suggest a protective role of the UCP2 protein in chronic inflammatory diseases.