Development of an AIDS vaccine using Sendai virus vectors
Development of an effective AIDS vaccine is crucial for the control of global human immunodeficiency virus type 1 (HIV-1) prevalence. We have developed a novel AIDS vaccine using a Sendai virus (SeV) vector and investigated its efficacy in a macaque AIDS model of simian immunodeficiency virus (SIV)...
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| Published in | Vaccine Vol. 33; no. 45; pp. 6061 - 6065 |
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| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier Ltd
09.11.2015
Elsevier Limited |
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| Online Access | Get full text |
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| Abstract | Development of an effective AIDS vaccine is crucial for the control of global human immunodeficiency virus type 1 (HIV-1) prevalence. We have developed a novel AIDS vaccine using a Sendai virus (SeV) vector and investigated its efficacy in a macaque AIDS model of simian immunodeficiency virus (SIV) infection. Its immunogenicity and protective efficacy have been shown, indicating that the SeV vector is a promising delivery tool for AIDS vaccines. Here, we describe the potential of SeV vector as a vaccine antigen delivery tool to induce effective immune responses against HIV-1 infection. |
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| AbstractList | Development of an effective AIDS vaccine is crucial for the control of global human immunodeficiency virus type 1 (HIV-1) prevalence. We have developed a novel AIDS vaccine using a Sendai virus (SeV) vector and investigated its efficacy in a macaque AIDS model of simian immunodeficiency virus (SIV) infection. Its immunogenicity and protective efficacy have been shown, indicating that the SeV vector is a promising delivery tool for AIDS vaccines. Here, we describe the potential of SeV vector as a vaccine antigen delivery tool to induce effective immune responses against HIV-1 infection. Abstract Development of an effective AIDS vaccine is crucial for the control of global human immunodeficiency virus type 1 (HIV-1) prevalence. We have developed a novel AIDS vaccine using a Sendai virus (SeV) vector and investigated its efficacy in a macaque AIDS model of simian immunodeficiency virus (SIV) infection. Its immunogenicity and protective efficacy have been shown, indicating that the SeV vector is a promising delivery tool for AIDS vaccines. Here, we describe the potential of SeV vector as a vaccine antigen delivery tool to induce effective immune responses against HIV-1 infection. |
| Author | Matano, Tetsuro Ishii, Hiroshi |
| Author_xml | – sequence: 1 givenname: Hiroshi surname: Ishii fullname: Ishii, Hiroshi organization: AIDS Research Center, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan – sequence: 2 givenname: Tetsuro surname: Matano fullname: Matano, Tetsuro email: tmatano@nih.go.jp organization: AIDS Research Center, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26232346$$D View this record in MEDLINE/PubMed |
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| Keywords | SIV Sendai virus vector HIV AIDS vaccine |
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| Snippet | Development of an effective AIDS vaccine is crucial for the control of global human immunodeficiency virus type 1 (HIV-1) prevalence. We have developed a novel... Abstract Development of an effective AIDS vaccine is crucial for the control of global human immunodeficiency virus type 1 (HIV-1) prevalence. We have... |
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| SubjectTerms | Acquired immune deficiency syndrome AIDS AIDS vaccine AIDS Vaccines - administration & dosage AIDS Vaccines - immunology Allergy and Immunology Animals Antibodies, Viral - blood Antibodies, Viral - immunology antigens CD8-Positive T-Lymphocytes - immunology Clinical Trials as Topic Drug resistance Genes Genetic Vectors HIV HIV infections HIV-1 - immunology Human immunodeficiency virus Human immunodeficiency virus 1 Humans immune response Immunization Immunogenicity Macaca Models, Animal Murine respirovirus SAIDS Vaccines - immunology Sendai virus Sendai virus - genetics Sendai virus vector Simian Acquired Immunodeficiency Syndrome - prevention & control Simian immunodeficiency virus SIV Swine influenza virus Vaccines Vaccines, Synthetic |
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| Title | Development of an AIDS vaccine using Sendai virus vectors |
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