Development of an AIDS vaccine using Sendai virus vectors

• Published in: Vaccine Vol. 33; no. 45; pp. 6061 - 6065
• Main Authors: Ishii, Hiroshi, Matano, Tetsuro
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 09.11.2015; Elsevier Limited
• Subjects: Acquired immune deficiency syndrome; AIDS; AIDS vaccine; AIDS Vaccines - administration & dosage; AIDS Vaccines - immunology; Allergy and Immunology; Animals; Antibodies, Viral - blood; Antibodies, Viral - immunology; antigens; CD8-Positive T-Lymphocytes - immunology; Clinical Trials as Topic; Drug resistance; Genes; Genetic Vectors; HIV; HIV infections; HIV-1 - immunology; Human immunodeficiency virus; Human immunodeficiency virus 1; Humans; immune response; Immunization; Immunogenicity; Macaca; Models, Animal; Murine respirovirus; SAIDS Vaccines - immunology; Sendai virus; Sendai virus - genetics; Sendai virus vector; Simian Acquired Immunodeficiency Syndrome - prevention & control; Simian immunodeficiency virus; SIV; Swine influenza virus; Vaccines; Vaccines, Synthetic; SIV; Sendai virus vector; HIV; AIDS vaccine
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2015.06.114

Development of an effective AIDS vaccine is crucial for the control of global human immunodeficiency virus type 1 (HIV-1) prevalence. We have developed a novel AIDS vaccine using a Sendai virus (SeV) vector and investigated its efficacy in a macaque AIDS model of simian immunodeficiency virus (SIV) infection. Its immunogenicity and protective efficacy have been shown, indicating that the SeV vector is a promising delivery tool for AIDS vaccines. Here, we describe the potential of SeV vector as a vaccine antigen delivery tool to induce effective immune responses against HIV-1 infection.