The DCC Protein and Prognosis in Colorectal Cancer

• Published in: The New England journal of medicine Vol. 335; no. 23; pp. 1727 - 1732
• Main Authors: Shibata, David, Reale, Michael A, Lavin, Philip, Silverman, Mark, Fearon, Eric R, Steele, Glenn, Jessup, John M, Loda, Massimo, Summerhayes, Ian C
• Format: Journal Article
• Language: English
• Published: Boston, MA Massachusetts Medical Society 05.12.1996
• Subjects: Aged; Biological and medical sciences; Biomarkers, Tumor - analysis; Biomarkers, Tumor - genetics; Cell Adhesion Molecules - analysis; Cell Adhesion Molecules - genetics; Colorectal cancer; Colorectal Neoplasms - chemistry; Colorectal Neoplasms - genetics; Colorectal Neoplasms - mortality; Colorectal Neoplasms - pathology; DCC Receptor; Female; Gastroenterology. Liver. Pancreas. Abdomen; Gene Expression; Genes, DCC - genetics; Humans; Immunohistochemistry; Life Tables; Male; Medical sciences; Middle Aged; Neoplasm Staging; Prognosis; Proportional Hazards Models; Proteins; Receptors, Cell Surface; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Survival Rate; Tumor Suppressor Proteins; Tumors; Human; Immunohistochemistry; Rectal disease; Carcinoma; Prognosis; Malignant tumor; Marker; Retrospective; Colonic disease; Pathology; Biopsy; Rectum; Digestive diseases; Intestinal disease; Colon
• ISSN: 0028-4793; 1533-4406
• DOI: 10.1056/NEJM199612053352303

Stage II or Dukes' stage B2 colorectal cancer accounts for approximately one third of the cases of colorectal cancer diagnosed annually in the United States. Surgery can cure 80 percent of these cases, but the prognosis is poor in the remainder, and unlike stage III colorectal cancer, stage II disease does not benefit from adjuvant therapy. 1 – 7 A recent study by Jen et al. found that allelic loss of chromosome 18q was linked to the prognosis in patients with stage II colorectal cancer. 8 The retention of both alleles predicted a favorable outcome, whereas the loss of one allele predicted a . . .