NDR1, a pathogen-induced component required for Arabidopsis disease resistance

• Published in: Science (American Association for the Advancement of Science) Vol. 278; no. 5345; pp. 1963 - 1965
• Main Authors: Century, K.S, Shapiro, A.D, Repetti, P.P, Dahlbeck, D, Holub, E, Staskawicz, B.J
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for the Advancement of Science 12.12.1997; American Association for the Advancement of Science; The American Association for the Advancement of Science
• Subjects: AGENT PATHOGENE; Amino Acid Sequence; Amino acids; Arabidopsis - genetics; Arabidopsis - microbiology; Arabidopsis Proteins; ARABIDOPSIS THALIANA; Bacteria; Biological and medical sciences; Botany; Chromosome Mapping; Chromosomes, Artificial, Yeast; Cloning, Molecular; Cosmids; Disease; DISEASE RESISTANCE; DNA; EXPRESION GENICA; EXPRESSION DES GENES; Fundamental and applied biological sciences. Psychology; Fungi; Gels; GENE; GENE EXPRESSION; Gene Expression Regulation, Plant; GENES; Genes, Plant; Genes. Genome; Genetic aspects; Genetics; Genomics; Immunity, Innate - genetics; Libraries; Membrane Proteins - chemistry; Molecular and cellular biology; Molecular genetics; Molecular Sequence Data; Natural immunity; Oomycetes - pathogenicity; Open Reading Frames; ORGANISMOS PATOGENOS; PATHOGENS; Plant diseases; Plant Diseases - genetics; Plant Proteins - chemistry; Plant Proteins - genetics; Plant Proteins - physiology; Plant-pathogen relationships; Plants; Pseudomonas - pathogenicity; RESISTANCE AUX MALADIES; RESISTENCIA A LA ENFERMEDAD; RNA; Signal Transduction; Space life sciences; Transcription Factors; Transformation, Genetic; Genetic mapping; Plant pathogen; Nucleotide sequence; Induction; Chromosome; Homology; Gene expression; Arabidopsis thaliana; Regulation(control); Microorganism resistance; Gene; Cruciferae; Dicotyledones; Angiospermae; Spermatophyta
• ISSN: 0036-8075; 1095-9203
• DOI: 10.1126/science.278.5345.1963

Plant disease resistance (R) genes confer an ability to resist infection by pathogens expressing specific corresponding avirulence genes. In Arabidopsis thaliana, resistance to both bacterial and fungal pathogens, mediated by several R gene products, requires the NDR1 gene. Positional cloning was used to isolate NDR1, which encodes a 660-base pair open reading frame. The predicted 219-amino acid sequence suggests that NDR1 may be associated with a membrane. NDR1 expression is induced in response to pathogen challenge and may function to integrate various pathogen recognition signals