Resolvin E1 Attenuates Chronic Pain-Induced Depression-Like Behavior in Mice: Possible Involvement of Chemerin Receptor ChemR23

• Published in: Biological & pharmaceutical bulletin Vol. 44; no. 10; pp. 1548 - 1550
• Main Authors: Suzuki, Hiroe, Otsuka, Takahisa, Hitora-Imamura, Natsuko, Ishimura, Kohei, Fukuda, Hayato, Fujiwara, Koichi, Shuto, Satoshi, Deyama, Satoshi, Minami, Masabumi
• Format: Journal Article
• Language: English; Japanese
• Published: Japan The Pharmaceutical Society of Japan 01.10.2021; Pharmaceutical Society of Japan; Japan Science and Technology Agency
• Subjects: Animal models; Animals; antidepressant; Antidepressants; Antidepressive Agents - administration & dosage; Chemokines - administration & dosage; Chemokines - metabolism; Chronic pain; Chronic Pain - complications; Chronic Pain - psychology; Depression - drug therapy; Depression - etiology; Depression - psychology; Disease Models, Animal; Eicosapentaenoic acid; Eicosapentaenoic Acid - administration & dosage; Eicosapentaenoic Acid - analogs & derivatives; Humans; Injections, Intraventricular; Intercellular Signaling Peptides and Proteins - administration & dosage; Intercellular Signaling Peptides and Proteins - metabolism; Male; Mental depression; Mice; n-3 polyunsaturated fatty acid; Neuralgia; Pain; Receptors, Chemokine - agonists; Receptors, Chemokine - metabolism; resolvin; Signal Transduction - drug effects; resolvin; pain; n-3 polyunsaturated fatty acid; antidepressant
• ISSN: 0918-6158; 1347-5215
• DOI: 10.1248/bpb.b21-00461

The antidepressant effect of eicosapentaenoic acid-derived bioactive lipid, resolvin E1 (RvE1), was examined in a murine model of chronic pain-induced depression using a tail suspension test. Because RvE1 reportedly possesses agonistic activity on a chemerin receptor ChemR23, we also examined the antidepressant effect of chemerin. Two weeks after surgery for unilateral spared nerve injury to prepare neuropathic pain model mice, immobility time was measured in a tail suspension test. Chronic pain significantly increased immobility time, and this depression-like behavior was attenuated by intracerebroventricular injection of RvE1 (1 ng) or chemerin (500 ng). These results demonstrate that RvE1 exerts an antidepressant effect in a murine model of chronic pain-induced depression, which is likely to be via ChemR23. RvE1 and its receptor may be promising targets to develop novel antidepressants.