Increased brain uptake and oxidation of acetate in heavy drinkers

• Published in: The Journal of clinical investigation Vol. 123; no. 4; pp. 1605 - 1614
• Main Authors: Jiang, Lihong, Gulanski, Barbara Irene, De Feyter, Henk M., Weinzimer, Stuart A., Pittman, Brian, Guidone, Elizabeth, Koretski, Julia, Harman, Susan, Petrakis, Ismene L., Krystal, John H., Mason, Graeme F.
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 01.04.2013
• Subjects: Acetates; Acetates - blood; Acetates - metabolism; Adenosine; Adult; Alcohol use; Alcoholics; Alcoholism - blood; Alcoholism - metabolism; Biomedical research; Blood Glucose; Brain; Brain - metabolism; Case-Control Studies; Dehydrogenases; Drinking of alcoholic beverages; Ethanol; Female; Glucose; Glutamic Acid - metabolism; Glutamine - metabolism; Humans; Hypoglycemia; Kinetics; Light; Male; Metabolic Networks and Pathways; Metabolism; Middle Aged; Models, Biological; Oxidation; Oxidation-Reduction; Oxidation-reduction reaction; Physiological aspects; Plasma; Spectrum analysis; Young Adult

When a person consumes ethanol, the body quickly begins to convert it to acetic acid, which circulates in the blood and can serve as a source of energy for the brain and other organs. This study used 13C magnetic resonance spectroscopy to test whether chronic heavy drinking is associated with greate...