Utility of Solid-State UV/Vis Spectra on the Evaluation of Photostability of Indomethacin Crystals

Evaluating the stability of drugs over ranges of various environmental conditions is necessary to ensure the quality of the drug throughout the shelf life. In this study, we used indomethacin, which is well known as a photosensitive drug, and evaluated the photostability of prepared crystals. HPLC a...

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Bibliographic Details
Published inChemical & pharmaceutical bulletin Vol. 66; no. 9; pp. 892 - 895
Main Authors Kiguchiya, Akihito, Teraoka, Reiko, Sakane, Toshiyasu
Format Journal Article
LanguageEnglish
Published Japan The Pharmaceutical Society of Japan 01.09.2018
Pharmaceutical Society of Japan
Japan Science and Technology Agency
Subjects
Chromatography, High Pressure Liquid
Crystallization
Crystals
Drug Stability
Drugs
Environmental conditions
Exposure
High-performance liquid chromatography
Indomethacin
Indomethacin - chemistry
Liquid chromatography
Photodegradation
Photolysis
Photosensitivity
photostability
Shelf life
Solid state
solid-state UV/Vis spectra
Solvents
Spectra
Spectrophotometry - methods
Stability analysis
stability prediction
Ultraviolet Rays
UVA region
solid-state UV/Vis spectra
stability prediction
photostability
UVA region
indomethacin
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Summary:Evaluating the stability of drugs over ranges of various environmental conditions is necessary to ensure the quality of the drug throughout the shelf life. In this study, we used indomethacin, which is well known as a photosensitive drug, and evaluated the photostability of prepared crystals. HPLC analysis revealed that all the indomethacin crystals were degraded by light exposure. However, the indomethacin crystals involving solvates had different degrees of photodegradation and different solid-state UV/Vis spectra. The value of the absorption integral in the UVA range related closely to the photodegradation of indomethacin crystals involving solvates. Therefore, it is easy to compare the photosensitivity among the crystals without actual analytical data, by use of a suitable analytical method and using light exposure samples. Moreover, it is possible to predict the value of photodegradation ratio from the solid-state UV/Vis spectra of indomethacin crystals. Therefore, this method may provide key information for selecting the most appropriate crystal form of photosensitive drugs.
Bibliography:ObjectType-Article-1
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content type line 23
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.c18-00389