Subclinical Mastitis in a European Multicenter Cohort: Prevalence, Impact on Human Milk (HM) Composition, and Association with Infant HM Intake and Growth

• Published in: Nutrients Vol. 12; no. 1; p. 105
• Main Authors: Samuel, Tinu Mary, De Castro, Carlos Antonio, Dubascoux, Stephane, Affolter, Michael, Giuffrida, Francesca, Billeaud, Claude, Picaud, Jean-Charles, Agosti, Massimo, Al-Jashi, Isam, Pereira, Almerinda Barroso, Costeira, Maria Jose, Silva, Maria Gorett, Marchini, Giovanna, Rakza, Thameur, Haaland, Kirsti, Stiris, Tom, Stoicescu, Silvia-Maria, Martínez-Costa, Cecilia, Vanpee, Mireilla, Domellöf, Magnus, Euridice, Castañeda-Gutiérrez, Thakkar, Sagar Kiran, Silva-Zolezzi, Irma
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.01.2020; MDPI
• Subjects: Albumins; Arachidonic acid; Babies; Breast feeding; Breast milk; Calcium; Composition; Correlation analysis; Cytokines; European population; Gestational age; human milk; Inflammation; Iron; Lactalbumin; Lactation; Lactoferrin; Lactose; Life Sciences; Linolenic acid; Longitudinal studies; longitudinal study; Mammary gland; Mammary glands; Manganese; Mastitis; Medicin och hälsovetenskap; Micronutrients; Milk; milk macronutrients; Minerals; Mothers; Permeability; Postpartum; Potassium; Selenium; Sodium; subclinical mastitis; Zinc; Sweden; France; United States > US; Switzerland; European population; human milk; longitudinal study; subclinical mastitis; milk macronutrients
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu12010105

Subclinical mastitis (SCM) is an inflammatory condition of the mammary gland. We examined the effects of SCM on human milk (HM) composition, infant growth, and HM intake in a mother-infant cohort from seven European countries. HM samples were obtained from 305 mothers at 2, 17, 30, 60, 90, and 120 days postpartum. SCM status was assessed using HM Sodium (Na): Potassium (K) ratio >0.6. Levels of different macro- and micronutrients were analyzed in HM. SCM prevalence in the first month of lactation was 35.4%. Mean gestational age at delivery was lower and birth by C-section higher in SCM mothers ( ≤ 0.001). HM concentrations of lactose, DHA, linolenic acid, calcium, and phosphorous ( < 0.05 for all) was lower, while total protein, alpha-lactalbumin, lactoferrin, albumin, arachidonic acid to DHA ratio, -6 to -3 ratio and minerals (iron, selenium, manganese, zinc, and copper) were higher ( < 0.001 for all) in mothers with SCM. There were no differences in infant growth and HM intake between non-SCM and SCM groups. We document, for the first time, in a large European standardized and longitudinal study, a high prevalence of SCM in early lactation and demonstrate that SCM is associated with significant changes in the macro- and micronutrient composition of HM. Future studies exploring the relation of SCM with breastfeeding behaviors and developmental outcomes are warranted.