NORTHIENAMYCIN AND 8-EPI-THIENAMYCIN, NEW CARBAPENEMS FROM STREPTOMYCES CATTLEYA

• Published in: Journal of antibiotics Vol. 36; no. 9; pp. 1109 - 1117
• Main Authors: WILSON, KENNETH E., KEMPF, AUGUST J., LIESCH, JERROLD M., ARISON, BYRON H.
• Format: Journal Article
• Language: English
• Published: Tokyo JAPAN ANTIBIOTICS RESEARCH ASSOCIATION 01.01.1983; Japan Antibiotics Research Association
• Subjects: 8-epi-thienamycin; Anti-Bacterial Agents - isolation & purification; Antibiotics; Antibiotics (antibacterial agents, antifungal agents); Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents; Applied microbiology; Bacteria - drug effects; Biological and medical sciences; Biotechnology; Chromatography, High Pressure Liquid; Fundamental and applied biological sciences. Psychology; Health. Pharmaceutical industry; Industrial applications and implications. Economical aspects; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Microbiology; northienamycin; Production of active biomolecules; Streptomyces - growth & development; Streptomyces cattleya; Structure-Activity Relationship; Thienamycins - isolation & purification; Thienamycins - toxicity; Antibiotic; Molecular structure; Production; Bacteria; Isolation; Antibacterial agent; Fermentation; In vitro; Biological activity; Comparative study
• ISSN: 0021-8820; 1881-1469
• DOI: 10.7164/antibiotics.36.1109

Two new carbapenem antibiotics, northienamycin and 8-epi-thienamycin have been isolated from culture broth of Streptomyces cattleya grown under conditions for thienamycin production. The isolation, structure elucidation and in vitro antibacterial spectra of the new carbapenems are reported. In addition, comparison of the in vitro potency of the correspond ing formamidine derivatives to that of MK787 is presented.