Lignans and Triterpenes from the Root of Pseuderanthemum carruthersii var. atropurpureum

• Published in: Chemical & pharmaceutical bulletin Vol. 60; no. 9; pp. 1125 - 1133
• Main Authors: Vo, Thi Nga, Nguyen, Phi Linh, Tuong, Lam Truong, Pratt, Lawrence Michael, Vo, Phung Nguyen, Nguyen, Kim Phi Phung, Nguyen, Ngoc Suong
• Format: Journal Article
• Language: English; Japanese
• Published: TOKYO The Pharmaceutical Society of Japan 01.09.2012; Pharmaceutical Society of Japan; Pharmaceutical Soc Japan; Japan Science and Technology Agency
• Subjects: Acanthaceae - chemistry; Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - isolation & purification; Antineoplastic Agents, Phytogenic - pharmacology; Cell Line, Tumor; Cell Survival - drug effects; Chemistry; Chemistry, Medicinal; Chemistry, Multidisciplinary; Humans; Life Sciences & Biomedicine; lignan; Lignans - chemistry; Lignans - isolation & purification; Lignans - pharmacology; Neoplasms - drug therapy; Pharmacology & Pharmacy; Physical Sciences; Plant Roots - chemistry; Pseuderanthemum; Science & Technology; triterpene; Triterpenes - chemistry; Triterpenes - isolation & purification; Triterpenes - pharmacology; triterpene; lignan; JAPONICA; NMR; BARK; Pseuderanthemum; STEREOCHEMISTRY; FLOWER BUDS
• ISSN: 0009-2363; 1347-5223
• DOI: 10.1248/cpb.c12-00222

Two new lignans, pseuderesinol (1), pseuderanoside (2) and a new triterpene, pseuderanic acid (3) were isolated from the dried root of Pseuderanthemum carruthersii (SEEM.) GUILL. var. atropurpureum (BULL.) FOSB. (Acanthaceae), together with ten known compounds, including five lignans, (+)-eudesmin (4), (+)-magnolin (5), (+)-syringaresinol (6), (+)-episyringaresinol (7), (+)-1-hydroxysyringaresinol (8) and five triterpenes, squalene (9), oleanolic acid (10), lupeol (11), betulin (12), betulinic acid (13). Their chemical structures were elucidated by 1D- and 2D-NMR, computational quantum chemistry, as well as high resolution-electrospray ionization (HR-ESI)-MS spectroscopic analysis. The acetylcholinesterase inhibition and cytotoxic activities against HeLa and MCF-7 cancer cell lines were evaluated on some purified compounds at the concentration of 100 µg/mL. Pseuderesinol (1) and magnolin (5) exhibited moderate cytotoxic activities against the MCF-7 cancer cell line.