Preparation and Characterization of Hydroxypropyl Methylcellulose/Polycarbophil Mucoadhesive Blend Films Using a Mixture Design Approach

• Published in: Chemical & pharmaceutical bulletin Vol. 65; no. 3; pp. 284 - 294
• Main Authors: Kraisit, Pakorn, Limmatvapirat, Sontaya, Nunthanid, Jurairat, Sriamornsak, Pornsak, Luangtana-Anan, Manee
• Format: Journal Article
• Language: English
• Published: Japan The Pharmaceutical Society of Japan 01.03.2017; Pharmaceutical Society of Japan; Japan Science and Technology Agency
• Subjects: Acrylic Resins - chemical synthesis; Acrylic Resins - chemistry; Atomic force microscopy; blend film; buccal drug delivery; Cubic lattice; Diffraction; Electron microscopes; Elongation; Fourier transforms; Hydrogen bonding; Hydrophobic and Hydrophilic Interactions; hydroxypropyl methylcellulose (HPMC); Hypromellose Derivatives - chemical synthesis; Hypromellose Derivatives - chemistry; Lattice design; Mechanical properties; Methylcellulose; Microscopy; mixture design; mucoadhesive film; polycarbophil; X-ray diffraction
• ISSN: 0009-2363; 1347-5223
• DOI: 10.1248/cpb.c16-00849

The objectives of this study were to prepare the hydroxypropyl methylcellulose (HPMC)/polycarbophil (PC) mucoadhesive blend film and to investigate the main and interaction effect of HPMC and PC mixtures on the physicochemical and mechanical properties of blend films using a simplex lattice mixture design approach. The cubic and quadratic models were selected to analyze mucoadhesive properties in terms of work of adhesion and maximum detachment force, respectively. It was shown that HPMC/PC blend film had higher mucoadhesive properties than pure HPMC film. The suitable models for analyzing swelling index of blend films at various times were assessed. The puncture strength, % elongation and hydrophilicity of films were also examined. The pure HPMC film displayed more homogeneous and smoother structures compared with the blend film, as observed by scanning electron microscope and atomic force microscopy. Intermolecular hydrogen bonding between HPMC and PC was detected using Fourier transform infrared and X-ray diffraction. Therefore, the blend film shows high potential for use as a buccal delivery system.