Effect of Food Thickener on Dissolution and Laxative Activity of Magnesium Oxide Tablets in Mice

• Published in: Biological & pharmaceutical bulletin Vol. 39; no. 4; pp. 648 - 651
• Main Authors: Tomita, Takashi, Goto, Hidekazu, Yoshimura, Yuya, Kato, Kazushige, Yoshida, Tadashi, Tanaka, Katsuya, Sumiya, Kenji, Kohda, Yukinao
• Format: Journal Article
• Language: English; Japanese
• Published: Japan The Pharmaceutical Society of Japan 01.04.2016; Pharmaceutical Society of Japan; Japan Science and Technology Agency
• Subjects: Agar - chemistry; agarose gel; Animals; dissolution rate; Food Additives - chemistry; food thickener; laxative activity; Laxatives - chemistry; Laxatives - pharmacology; magnesium oxide; Magnesium Oxide - chemistry; Magnesium Oxide - pharmacology; Male; Mice, Inbred ICR; Polysaccharides, Bacterial - chemistry; Solubility; Tablets; xanthan gum

The present study examined the dissolution of magnesium oxide (MgO) from MgO tablets placed in a food thickening agent (food thickener) and its effects on laxative activity. We prepared mixtures of MgO tablets suspended in an aqueous suspension and food thickeners in order to evaluate the dissolutio...