Effect of Food Thickener on Dissolution and Laxative Activity of Magnesium Oxide Tablets in Mice

• Published in: Biological & pharmaceutical bulletin Vol. 39; no. 4; pp. 648 - 651
• Main Authors: Tomita, Takashi, Goto, Hidekazu, Yoshimura, Yuya, Kato, Kazushige, Yoshida, Tadashi, Tanaka, Katsuya, Sumiya, Kenji, Kohda, Yukinao
• Format: Journal Article
• Language: English; Japanese
• Published: Japan The Pharmaceutical Society of Japan 01.04.2016; Pharmaceutical Society of Japan; Japan Science and Technology Agency
• Subjects: Agar - chemistry; agarose gel; Animals; dissolution rate; Food Additives - chemistry; food thickener; laxative activity; Laxatives - chemistry; Laxatives - pharmacology; magnesium oxide; Magnesium Oxide - chemistry; Magnesium Oxide - pharmacology; Male; Mice, Inbred ICR; Polysaccharides, Bacterial - chemistry; Solubility; Tablets; xanthan gum
• ISSN: 0918-6158; 1347-5215
• DOI: 10.1248/bpb.b15-00848

The present study examined the dissolution of magnesium oxide (MgO) from MgO tablets placed in a food thickening agent (food thickener) and its effects on laxative activity. We prepared mixtures of MgO tablets suspended in an aqueous suspension and food thickeners in order to evaluate the dissolution of MgO. The results of the dissolution tests revealed that agar-based food thickeners did not affect the MgO dissolution. In contrast, some xanthan gum-based food-thickener products show dissolution rates with certain mixtures containing disintegrated MgO tablets suspended in a food thickener that decrease over time. However, other xanthan gum-based food-thickener products show dissolution rates that decrease immediately after mixing, regardless of the time they were allowed to stand. In order to investigate the laxative activity of MgO, we orally administered a mixture of MgO suspension and food thickener to mice and observed their bowel movements. The animal experiments showed that when agar-based food thickeners were used, the laxative activity of MgO was not affected, but it decreased when xanthan gum-based food thickeners were used.