Secretomes from Mesenchymal Stem Cells against Acute Kidney Injury: Possible Heterogeneity

• Published in: Stem cells international Vol. 2018; no. 2018; pp. 1 - 14
• Main Authors: Tsuji, Kenji, Wada, Jun, Kitamura, Shinji
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2018; Hindawi; Hindawi Limited; Wiley
• Subjects: Aging; Analysis; Angiotensin II; Animal models; Apoptosis; Bone marrow; Cell growth; Chemokines; Cytokines; Epidermal growth factor; Exosomes; Granulocytes; Heterogeneity; Hypoxia; Immunology; Inflammation; Injuries; Injury analysis; Insulin-like growth factors; Ischemia; Kidneys; Kinases; Ligands; Mesenchymal stem cells; Mesenchyme; Messenger RNA; MicroRNA; miRNA; Paracrine signalling; Physiology; Proteins; Regeneration; Reperfusion; Reperfusion injury; Researchers; Review; Stem cell transplantation; Stem cells; Stimuli; TNF inhibitors; Trophic factors; Tumor necrosis factor-TNF; Vesicles; United States > US
• ISSN: 1687-966X; 1687-9678; 1687-9678
• DOI: 10.1155/2018/8693137

A kidney has the ability to regenerate itself after a variety of renal injuries. Mesenchymal stem cells (MSCs) have been shown to ameliorate tissue damages during renal injuries and diseases. The regenerations induced by MSCs are primarily mediated by the paracrine release of soluble factors and extracellular vesicles, including exosomes and microvesicles. Extracellular vesicles contain proteins, microRNAs, and mRNAs that are transferred into recipient cells to induce several repair signaling pathways. Over the past few decades, many studies identified trophic factors from MSCs, which attenuate renal injury in a variety of animal acute kidney injury models, including renal ischemia-reperfusion injury and drug-induced renal injury, using microarray and proteomic analysis. Nevertheless, these studies have revealed the heterogeneity of trophic factors from MSCs that depend on the cell origins and different stimuli including hypoxia, inflammatory stimuli, and aging. In this review article, we summarize the secretomes and regenerative mechanisms induced by MSCs and highlight the possible heterogeneity of trophic factors from different types of MSC and different circumstances for renal regeneration.