Intestinal Dysbiosis and Rheumatoid Arthritis: A Link between Gut Microbiota and the Pathogenesis of Rheumatoid Arthritis

Characterization and understanding of gut microbiota has recently increased representing a wide research field, especially in autoimmune diseases. Gut microbiota is the major source of microbes which might exert beneficial as well as pathogenic effects on human health. Intestinal microbiome’s role a...

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Published in	Journal of Immunology Research Vol. 2017; no. 2017; pp. 1 - 13
Main Authors	García-Mena, Jaime, Pizano-Zárate, María Luisa, Montiel-Jarquín, Alvaro José, Romero Figueroa, Socorro, Horta-Baas, Gabriel, Ramírez Durán, Ninfa
Format	Journal Article
Language	English
Published	Cairo, Egypt Hindawi Publishing Corporation 01.01.2017 Hindawi John Wiley & Sons, Inc Wiley
Subjects	Animals Antigens Arthritis Arthritis, Rheumatoid Autoimmune diseases Autoimmunity B cells Development and progression Diet Digestive system Dysbacteriosis Dysbiosis - immunology Gastrointestinal Microbiome - immunology Gastrointestinal tract Health aspects Health risk assessment Humans Immune system Immunoglobulins Immunology Inflammation Intestinal microflora Intestine Intestines - microbiology Medical research Medicine, Experimental Microbiota (Symbiotic organisms) Nutrition research Pathogenesis Probiotics Review Rheumatoid arthritis Rheumatoid factor Rheumatology Studies Vegetarianism Mexico
Online Access	Get full text
ISSN	2314-8861 2314-7156 2314-7156
DOI	10.1155/2017/4835189

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Abstract	Characterization and understanding of gut microbiota has recently increased representing a wide research field, especially in autoimmune diseases. Gut microbiota is the major source of microbes which might exert beneficial as well as pathogenic effects on human health. Intestinal microbiome’s role as mediator of inflammation has only recently emerged. Microbiota has been observed to differ in subjects with early rheumatoid arthritis compared to controls, and this finding has commanded this study as a possible autoimmune process. Studies with intestinal microbiota have shown that rheumatoid arthritis is characterized by an expansion and/or decrease of bacterial groups as compared to controls. In this review, we present evidence linking intestinal dysbiosis with the autoimmune mechanisms involved in the development of rheumatoid arthritis.
AbstractList	Characterization and understanding of gut microbiota has recently increased representing a wide research field, especially in autoimmune diseases. Gut microbiota is the major source of microbes which might exert beneficial as well as pathogenic effects on human health. Intestinal microbiome’s role as mediator of inflammation has only recently emerged. Microbiota has been observed to differ in subjects with early rheumatoid arthritis compared to controls, and this finding has commanded this study as a possible autoimmune process. Studies with intestinal microbiota have shown that rheumatoid arthritis is characterized by an expansion and/or decrease of bacterial groups as compared to controls. In this review, we present evidence linking intestinal dysbiosis with the autoimmune mechanisms involved in the development of rheumatoid arthritis. Characterization and understanding of gut microbiota has recently increased representing a wide research field, especially in autoimmune diseases. Gut microbiota is the major source of microbes which might exert beneficial as well as pathogenic effects on human health. Intestinal microbiome's role as mediator of inflammation has only recently emerged. Microbiota has been observed to differ in subjects with early rheumatoid arthritis compared to controls, and this finding has commanded this study as a possible autoimmune process. Studies with intestinal microbiota have shown that rheumatoid arthritis is characterized by an expansion and/or decrease of bacterial groups as compared to controls. In this review, we present evidence linking intestinal dysbiosis with the autoimmune mechanisms involved in the development of rheumatoid arthritis.Characterization and understanding of gut microbiota has recently increased representing a wide research field, especially in autoimmune diseases. Gut microbiota is the major source of microbes which might exert beneficial as well as pathogenic effects on human health. Intestinal microbiome's role as mediator of inflammation has only recently emerged. Microbiota has been observed to differ in subjects with early rheumatoid arthritis compared to controls, and this finding has commanded this study as a possible autoimmune process. Studies with intestinal microbiota have shown that rheumatoid arthritis is characterized by an expansion and/or decrease of bacterial groups as compared to controls. In this review, we present evidence linking intestinal dysbiosis with the autoimmune mechanisms involved in the development of rheumatoid arthritis.
Audience	Academic
Author	Romero Figueroa, Socorro Montiel-Jarquín, Alvaro José García-Mena, Jaime Ramírez Durán, Ninfa Horta-Baas, Gabriel Pizano-Zárate, María Luisa
AuthorAffiliation	1 Servicio de Reumatología, Hospital General Regional 220, Instituto Mexicano del Seguro Social, Toluca, MEX, Mexico 3 Jefatura de División de Investigación en Salud, Unidad Médica de Alta Especialidad Hospital de Traumatología y Ortopedia, Instituto Mexicano del Seguro Social, Puebla, PUE, Mexico 5 Departamento de Genética y Biología Molecular, Cinvestav, Av IPN 2508 Col Zacatenco, Ciudad de México, Mexico 2 Coordinación de Investigación en Salud, Delegación Estado de México Poniente, Instituto Mexicano del Seguro Social, Toluca, MEX, Mexico 4 Departamento de Nutrición y Bioprogramación, Instituto Nacional de Perinatología, Secretaría de Salud, Ciudad de México, Mexico 6 Laboratory of Medical and Environmental Microbiology, Department of Medicine, Autonomous University of the State of Mexico, Toluca, MEX, Mexico
AuthorAffiliation_xml	– name: 2 Coordinación de Investigación en Salud, Delegación Estado de México Poniente, Instituto Mexicano del Seguro Social, Toluca, MEX, Mexico – name: 5 Departamento de Genética y Biología Molecular, Cinvestav, Av IPN 2508 Col Zacatenco, Ciudad de México, Mexico – name: 1 Servicio de Reumatología, Hospital General Regional 220, Instituto Mexicano del Seguro Social, Toluca, MEX, Mexico – name: 3 Jefatura de División de Investigación en Salud, Unidad Médica de Alta Especialidad Hospital de Traumatología y Ortopedia, Instituto Mexicano del Seguro Social, Puebla, PUE, Mexico – name: 4 Departamento de Nutrición y Bioprogramación, Instituto Nacional de Perinatología, Secretaría de Salud, Ciudad de México, Mexico – name: 6 Laboratory of Medical and Environmental Microbiology, Department of Medicine, Autonomous University of the State of Mexico, Toluca, MEX, Mexico
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BackLink	https://www.ncbi.nlm.nih.gov/pubmed/28948174$$D View this record in MEDLINE/PubMed
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ContentType	Journal Article
Copyright	Copyright © 2017 Gabriel Horta-Baas et al. COPYRIGHT 2017 John Wiley & Sons, Inc. Copyright © 2017 Gabriel Horta-Baas et al.; This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2017 Gabriel Horta-Baas et al. 2017
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Snippet	Characterization and understanding of gut microbiota has recently increased representing a wide research field, especially in autoimmune diseases. Gut...
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SubjectTerms	Animals Antigens Arthritis Arthritis, Rheumatoid Autoimmune diseases Autoimmunity B cells Development and progression Diet Digestive system Dysbacteriosis Dysbiosis - immunology Gastrointestinal Microbiome - immunology Gastrointestinal tract Health aspects Health risk assessment Humans Immune system Immunoglobulins Immunology Inflammation Intestinal microflora Intestine Intestines - microbiology Medical research Medicine, Experimental Microbiota (Symbiotic organisms) Nutrition research Pathogenesis Probiotics Review Rheumatoid arthritis Rheumatoid factor Rheumatology Studies Vegetarianism
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Title	Intestinal Dysbiosis and Rheumatoid Arthritis: A Link between Gut Microbiota and the Pathogenesis of Rheumatoid Arthritis
URI	https://search.emarefa.net/detail/BIM-1181875 https://dx.doi.org/10.1155/2017/4835189 https://www.ncbi.nlm.nih.gov/pubmed/28948174 https://www.proquest.com/docview/1937588950 https://www.proquest.com/docview/1943287781 https://pubmed.ncbi.nlm.nih.gov/PMC5602494 https://doaj.org/article/0c9867cb3ac144f09155ec1d0265a8c2
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