Intestinal Dysbiosis and Rheumatoid Arthritis: A Link between Gut Microbiota and the Pathogenesis of Rheumatoid Arthritis

Characterization and understanding of gut microbiota has recently increased representing a wide research field, especially in autoimmune diseases. Gut microbiota is the major source of microbes which might exert beneficial as well as pathogenic effects on human health. Intestinal microbiome’s role a...

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Bibliographic Details
Published inJournal of Immunology Research Vol. 2017; no. 2017; pp. 1 - 13
Main Authors García-Mena, Jaime, Pizano-Zárate, María Luisa, Montiel-Jarquín, Alvaro José, Romero Figueroa, Socorro, Horta-Baas, Gabriel, Ramírez Durán, Ninfa
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Publishing Corporation 01.01.2017
Hindawi
John Wiley & Sons, Inc
Wiley
Subjects
Animals
Antigens
Arthritis
Arthritis, Rheumatoid
Autoimmune diseases
Autoimmunity
B cells
Development and progression
Diet
Digestive system
Dysbacteriosis
Dysbiosis - immunology
Gastrointestinal Microbiome - immunology
Gastrointestinal tract
Health aspects
Health risk assessment
Humans
Immune system
Immunoglobulins
Immunology
Inflammation
Intestinal microflora
Intestine
Intestines - microbiology
Medical research
Medicine, Experimental
Microbiota (Symbiotic organisms)
Nutrition research
Pathogenesis
Probiotics
Review
Rheumatoid arthritis
Rheumatoid factor
Rheumatology
Studies
Vegetarianism
Mexico
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Summary:Characterization and understanding of gut microbiota has recently increased representing a wide research field, especially in autoimmune diseases. Gut microbiota is the major source of microbes which might exert beneficial as well as pathogenic effects on human health. Intestinal microbiome’s role as mediator of inflammation has only recently emerged. Microbiota has been observed to differ in subjects with early rheumatoid arthritis compared to controls, and this finding has commanded this study as a possible autoimmune process. Studies with intestinal microbiota have shown that rheumatoid arthritis is characterized by an expansion and/or decrease of bacterial groups as compared to controls. In this review, we present evidence linking intestinal dysbiosis with the autoimmune mechanisms involved in the development of rheumatoid arthritis.
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Academic Editor: Mitesh Dwivedi
ISSN:2314-8861
2314-7156
2314-7156
DOI:10.1155/2017/4835189