Systemic antibiotics and debridement of peri-implant mucositis. A randomized clinical trial

• Published in: Journal of clinical periodontology Vol. 39; no. 6; pp. 574 - 581
• Main Authors: Hallström, Hadar, Persson, G. Rutger, Lindgren, Susann, Olofsson, Maria, Renvert, Stefan
• Format: Journal Article
• Language: English
• Published: Oxford Blackwell Publishing Ltd 01.06.2012; Blackwell
• Subjects: Administration, Oral; Adult; Aged; Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - therapeutic use; Antibiotics; Azithromycin - administration & dosage; Azithromycin - therapeutic use; Bacterial infections; Bacteroides - isolation & purification; Biological and medical sciences; Campylobacter - isolation & purification; Clinical Medicine; Clinical outcomes; Combined Modality Therapy; Dental Implantation, Endosseous - adverse effects; Dental Implants - adverse effects; Dental Implants - microbiology; Dentistry; DNA, Bacterial - analysis; Facial bones, jaws, teeth, parodontium: diseases, semeiology; Fusobacterium nucleatum - isolation & purification; Humans; Klinisk medicin; Linear Models; Medical and Health Sciences; Medical sciences; Medicin och hälsovetenskap; microbiology; Middle Aged; Mucositis - drug therapy; Mucositis - etiology; Mucositis - microbiology; Mucositis - therapy; Non tumoral diseases; Odontologi; Otorhinolaryngology. Stomatology; peri-implant disease; peri-implant mucositis; Peri-Implantitis - drug therapy; Peri-Implantitis - microbiology; Peri-Implantitis - therapy; Periodontal Debridement; Periodontal Index; Single-Blind Method; Statistics, Nonparametric; Stomatitis - drug therapy; Stomatitis - etiology; Stomatitis - microbiology; Stomatitis - therapy; therapy; Transplants & implants; Treatment Outcome; Mucositis; peri-implant mucositis; Implant; Microbiology; therapy; Dentistry; Antibiotic; Treatment; Debridment; Clinical trial; Disseminated; antibiotics; peri-implant disease
• ISSN: 0303-6979; 1600-051X; 1600-051X
• DOI: 10.1111/j.1600-051X.2012.01884.x

Background This RCT compared non‐surgical treatment of peri‐implant mucositis with or without systemic antibiotics. Materials and Methods Forty‐eight subjects received non‐surgical debridement with or without systemic Azithromax ® (4 days), and were followed during 6 months. The checkerboard DNA‐DNA hybridization method was used to analyse the microbiological material. Results Five subjects were excluded due to antibiotic medication during follow‐up. At baseline,1 and 3 months no group differences were found. Statistical analysis failed to demonstrate differences in probing pocket depths (PPD) values at 6 months (Mean diff PPD: 0.5 mm, SE: ±0.4 mm, 95% CI: −0.2, 1.3, p = 0.16). Mean% implant bleeding decreased between baseline and month 6 from 82.6% to 27.3% in the test, and from 80.0% to 47.5% in the control group (p < 0.02). Throughout the study, no study group differences in bacterial counts were found. Conclusion No short‐term differences were found between study groups. The clinical improvements observed at 6 months may be attributed to improvements in oral hygiene. The present study does not provide evidence for the use of systemic antibiotics in treatment of peri‐implant mucositis.