SOD Enzymes and Microbial Pathogens: Surviving the Oxidative Storm of Infection

  [...]Mn and Fe SODs are generally intracellular/cytosolic while Cu/Zn SODs are extracellular/periplasmic (Fig 1). Custom SOD Enzymes for Bacterial Pathogenesis The accepted nomenclature for bacterial SODs is SodA, SodB, and SodC for the Mn, Fe, and Cu/Zn SODs, respectively. Because superoxide does...

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Published inPLoS pathogens Vol. 12; no. 1; p. e1005295
Main Authors Broxton, Chynna N, Culotta, Valeria C
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 01.01.2016
Public Library of Science (PLoS)
Subjects
Animals
Bacteria
Bacteriology
Catalysis
E coli
Enzymes
Funding
Fungi
Gram-negative bacteria
Health aspects
Host-parasite relationships
Host-Pathogen Interactions - immunology
Humans
Infections
Laboratories
Observations
Oxidative Stress - immunology
Pathogenesis
Pathogenic microorganisms
Pathogens
Pearls
Reactive oxygen species
Superoxide Dismutase - immunology
Tuberculosis
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Summary:  [...]Mn and Fe SODs are generally intracellular/cytosolic while Cu/Zn SODs are extracellular/periplasmic (Fig 1). Custom SOD Enzymes for Bacterial Pathogenesis The accepted nomenclature for bacterial SODs is SodA, SodB, and SodC for the Mn, Fe, and Cu/Zn SODs, respectively. Because superoxide does not generally cross biological membranes, the intracellular SodA and SodB largely remove intracellular or metabolic sources of superoxide while the periplasmic/extracellular SodC directly combats superoxide from the animal host.
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The authors have declared that no competing interests exist.
ISSN:1553-7374
1553-7366
1553-7374
DOI:10.1371/journal.ppat.1005295