Diffuse Nodular Lymphoid Hyperplasia of the Intestine Caused by Common Variable Immunodeficiency and Refractory Giardiasis

Diffuse nodular lymphoid hyperplasia of the gastrointestinal tract is a rare disease characterized by numerous small polypoid nodules in the small intestine, large intestine, or both. It is associated with immunodeficiency and infection, such as Giardia lamblia and Helicobacter pylori. Although diff...

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Published inInternal Medicine Vol. 56; no. 3; pp. 283 - 287
Main Authors Choi, Jung Hye, Han, Dong Soo, Kim, Jieun, Yi, Kijong, Oh, Young-Ha, Kim, Yongsoo
Format Journal Article
LanguageEnglish
Published Japan The Japanese Society of Internal Medicine 01.01.2017
Japan Science and Technology Agency
Subjects
Adult
Case Report
Common variable immunodeficiency
Common Variable Immunodeficiency - complications
Diagnosis, Differential
diffuse lymphoid hyperplasia
Duodenal Diseases - diagnosis
Duodenal Diseases - etiology
Duodenal Diseases - pathology
Female
Gastrointestinal tract
Giardia lamblia
Giardiasis
Giardiasis - complications
Helicobacter pylori
Humans
Hyperplasia
Hyperplasia - diagnosis
Hyperplasia - etiology
Hyperplasia - pathology
Immunologic Deficiency Syndromes - diagnosis
Immunologic Deficiency Syndromes - etiology
Immunologic Deficiency Syndromes - pathology
Infections
Internal medicine
Large intestine
Lymphoid tissue
Lymphoproliferative Disorders - diagnosis
Lymphoproliferative Disorders - etiology
Lymphoproliferative Disorders - pathology
Nodular lymphoid hyperplasia
Nodules
Small intestine
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Summary:Diffuse nodular lymphoid hyperplasia of the gastrointestinal tract is a rare disease characterized by numerous small polypoid nodules in the small intestine, large intestine, or both. It is associated with immunodeficiency and infection, such as Giardia lamblia and Helicobacter pylori. Although diffuse nodular lymphoid hyperplasia associated with common variable immunodeficiency (CVID) and giardiasis is already known, a few studies have reported a regression of the lymphoid nodules after the eradication of infection. We herein describe a case of diffuse nodular lymphoid hyperplasia of the intestine associated with CVID and refractory giardiasis that markedly improved after successfully treating giardiasis.
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Correspondence to Dr.　Jung Hye Choi, jhcmd@hanyang.ac.kr
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.56.7305