Applications of microarrays in pathogen detection and biodefence

The microarray is a platform with wide-ranging potential in biodefence. Owing to the high level of throughput attainable through miniaturization, microarrays have accelerated the ability to respond in an epidemic or crisis. Extending beyond diagnostics, recent studies have applied microarrays as a r...

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Published inTrends in biotechnology (Regular ed.) Vol. 27; no. 1; pp. 53 - 61
Main Authors Uttamchandani, Mahesh, Neo, Jia Ling, Ong, Brandon Ngiap Zhung, Moochhala, Shabbir
Format Journal Article
LanguageEnglish
Published Cambridge, MA Elsevier Ltd 01.01.2009
[London]: Elsevier Science
Cell Press
Elsevier Limited
Subjects
Avian flu
Bacteria - isolation & purification
Biological and medical sciences
Biological Warfare - prevention & control
Biological Warfare Agents
Biotechnology
Bioterrorism - prevention & control
Deoxyribonucleic acid
DNA
Fundamental and applied biological sciences. Psychology
Gene expression
Genomes
Internal Medicine
Medical research
Methods. Procedures. Technologies
Microarray Analysis - trends
Mortality
Organisms
Others
Pathogens
Public health
Technological change
Threats
Various methods and equipments
Viruses - isolation & purification
Biodefense
Pathogenic
DNA chip
Protein microarray
Review
Miniaturization
Detection
Microarray
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Summary:The microarray is a platform with wide-ranging potential in biodefence. Owing to the high level of throughput attainable through miniaturization, microarrays have accelerated the ability to respond in an epidemic or crisis. Extending beyond diagnostics, recent studies have applied microarrays as a research tool towards understanding the etiology and pathogenicity of dangerous pathogens, as well as in vaccine development. The original emphasis was on DNA microarrays, but the range now includes protein, antibody and carbohydrate microarrays, and research groups have exploited this diversity to further extend microarray applications in the area of biodefence. Here, we discuss the impact and contributions of the growing range of microarrays and emphasize the concepts that might shape the future of biodefence research.
Bibliography:http://dx.doi.org/10.1016/j.tibtech.2008.09.004
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ISSN:0167-7799
1879-3096
DOI:10.1016/j.tibtech.2008.09.004