Restoration by MDP-Lys(L18) of Resistance to Pseudomonas Pneumonia in Immunosuppressed Guinea Pigs

• Published in: MICROBIOLOGY and IMMUNOLOGY Vol. 28; no. 9; pp. 1077 - 1082
• Main Authors: Otani, Tsuyoshi, Katami, Kazuei, Une, Tsutomu, Osada, Yasuaki, Ogawa, Hidemasa
• Format: Journal Article
• Language: English
• Published: Tokyo Blackwell Publishing Ltd 01.01.1984; Center For Academic Publications Japan; Center for Academic Publications Japan
• Subjects: Acetylmuramyl-Alanyl-Isoglutamine - analogs & derivatives; Acetylmuramyl-Alanyl-Isoglutamine - pharmacology; Animals; Bacterial diseases; Biological and medical sciences; Experimental bacterial diseases and models; Female; Guinea Pigs; Immune Tolerance - drug effects; Infectious diseases; Medical sciences; Pneumonia - drug therapy; Pneumonia - immunology; Pneumonia - pathology; Pseudomonas aeruginosa; Pseudomonas Infections - drug therapy; Pseudomonas Infections - immunology; Pseudomonas Infections - pathology; Pseudomonadales; Pneumonia; Respiratory disease; Rodentia; Immune reconstitution; Infection; Vertebrata; Immunosuppression; Experimental disease; Mammalia; Guinea pig; Immune resistance; Glycopeptide; Immunotherapy; Bacteriosis; Bacteria; Pseudomonadaceae; Pseudomonas aeruginosa
• ISSN: 0385-5600; 1348-0421
• DOI: 10.1111/j.1348-0421.1984.tb00764.x

Muramyl dipeptide (MDP) and its analogs have been considered for improving host defense, and are effective in combination with antibiotics in treating infections in immunosuppressed and immunodeficient patients. This paper deals with the protective effect of MDP-Lys (L18) against experimental pneumonia with P. aeruginosa in immunosuppressed guinea pigs and with histopathological manifestation possibly responsible for its effectiveness.