Evaluation of the effectiveness of combination therapy of recurrent anogenital (venereal) warts: results of an observational comparative clinical study

• Published in: Vestnik dermatologij i venerologij Vol. 100; no. 4; pp. 60 - 67
• Main Authors: Rakhmatulina, Margarita R., Bolshenko, Natalia V., Novoselova, Elena Yu, Pak, Victoria L., Stovbun, Sergei V., Arseenkova, Olga Yu
• Format: Journal Article
• Language: English
• Published: 26.08.2024
• ISSN: 0042-4609; 2313-6294
• DOI: 10.25208/vdv16799

Background. In case of recurrent forms of the disease, combination therapy with the use of inducers interferons may be recommended. Aims. To study the effectiveness of polysaccharides of Solanum tuberosum shoots (Panavir gel 0.002%) in the combined therapy of recurrent anogenital warts. Methods. 60 patients: group 1 (n = 30) underwent radiowave destruction with Panavir gel 0.002% externally 2 times a day for 5 days before and 10 days after destruction, group 2 (n = 30) — radiowave destruction. Results. Absence of itching and pain by day 5 was recorded in 27 (90.0%) patients of group 1 and 12 (40.0%) of group 2, after 10 days — in 30 (100%) and 26 (86.7%) (χ² = 4.285). Inflammatory erythema, edema and infiltration were absent after 10 days in all patients of group 1, but persisted in 7 (23,3%),12 (40.0%) and 2 (6.7%) patients of group 2 (χ² = 7.924). Epithelialization was observed for 5 days in 18 (60.0%) patients of group 1 and 10 (33.3%) patients of group 2, after 10 days — in 30 (100%) and 28 (93.3%) patients (χ² = 4.285). 90 days after therapy, relapses of the disease were recorded in 2 (6.7%) patients of group 1 and 6 (20.0%) patients of group 2 (p = 0.499), HPV elimination was observed in 11 (36.7%) and 10 (33.3%) patients (p = 0.967). Conclusion. The effectiveness of Panavir gel 0.002% in the complex therapy of anogenital warts has been established in terms of reducing the severity of subjective and objective symptoms of the disease, as well as reducing the frequency of recurrence of rashes.