Factors Associated with Severe Leptospirosis, Martinique, 2010-2013

• Published in: Emerging infectious diseases Vol. 21; no. 12; pp. 2221 - 2224
• Main Authors: Hochedez, Patrick, Theodose, Rafaelle, Olive, Claude, Bourhy, Pascale, Hurtrel, Guillaume, Vignier, Nicolas, Mehdaoui, Hossein, Valentino, Ruddy, Martinez, Roland, Delord, Jean-Marie, Herrmann, Cécile, Lamaury, Isabelle, Césaire, Raymond, Picardeau, Mathieu, Cabié, André
• Format: Journal Article
• Language: English
• Published: United States U.S. National Center for Infectious Diseases 01.12.2015; Centers for Disease Control and Prevention
• Subjects: Adult; Animals; Care and treatment; Complications and side effects; Development and progression; Disease Outbreaks; Dispatch; Dog Diseases; Dog Diseases - epidemiology; Dog Diseases - genetics; Dog Diseases - pathology; Dogs; Factors Associated with Severe Leptospirosis, Martinique, 2010–2013; Female; Humans; Leptospira interrogans; leptospiremia; Leptospirosis; Leptospirosis - blood; Leptospirosis - epidemiology; Leptospirosis - genetics; Life Sciences; Male; Martinique; Martinique - epidemiology; Microbiology and Parasitology; Middle Aged; Patient outcomes; qPCR; serogroup Icterohaemorrhagiae; severe leptospirosis; Thrombin; Zoonoses; Zoonoses - epidemiology; Martinique; bacteria; quantitative PCR; serogroup Icterohaemorrhagiae; Martinique; Leptospira interrogans; leptospiremia; qPCR; severe leptospirosis
• ISSN: 1080-6040; 1080-6059
• DOI: 10.3201/eid2112.141099

To identify factors associated with disease severity, we examined 102 patients with quantitative PCR-confirmed leptospirosis in Martinique during 2010-2013. Associated factors were hypotension, chest auscultation abnormalities, icterus, oligo/anuria, thrombocytopenia, prothrombin time <68%, high levels of leptospiremia, and infection with L. interrogans serovar Icterohaemorrhagiae/Copenhageni.