Antiproliferative activity of root extract from gentian plant (Gentiana triflora) on cultured and implanted tumor cells

We describe a novel pharmacological activity of the gentian root, an ingredient of Chinese medicines. Root extract from Gentiana triflora triggered cell death of human Daudi cells in culture. In addition, daily administration of the extract to mice inhibited growth of implanted solid tumors. Extract...

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Published inBioscience, biotechnology, and biochemistry Vol. 70; no. 4; pp. 1046 - 1048
Main Authors Matsukawa, K.(Iwate Univ., Morioka (Japan)), Ogata, M, Hikage, T, Minami, H, Shimotai, Y, Saitoh, Y, Yamashita, T, Ouchi, A, Tsutsumi, R, Fujioka, T, Tsutsumi, K
Format Journal Article
LanguageEnglish
Published Tokyo Japan Society for Bioscience, Biotechnology, and Agrochemistry 2006
Japan Society for Bioscience Biotechnology and Agrochemistry
Oxford University Press
Subjects
Animals
antiproliferative activity
antitumor activity
Biological and medical sciences
cell death
Cell Line, Tumor
Cell Proliferation - drug effects
Cell Shape
Cell Transplantation
Chinese medicine
EXTRACTOS VEGETALES
EXTRAIT D'ORIGINE VEGETALE
Fundamental and applied biological sciences. Psychology
GENTIANA
Gentiana - chemistry
Gentiana triflora
Male
NEOPLASMAS
NEOPLASME
NEOPLASMS
Neoplasms - pathology
PLANT EXTRACTS
Plant Extracts - chemistry
Plant Extracts - pharmacology
Plant Roots - chemistry
RACINE
RAICES
ROOTS
TOXICIDAD
TOXICITE
TOXICITY
Antineoplastic agent
Medicine
Gentiana triflora
Chinese medicine
Root
Cell death
antitumor activity
Extract
Tumor cell
antiproliferative activity
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Summary:We describe a novel pharmacological activity of the gentian root, an ingredient of Chinese medicines. Root extract from Gentiana triflora triggered cell death of human Daudi cells in culture. In addition, daily administration of the extract to mice inhibited growth of implanted solid tumors. Extract treatment of cultured cells resulted in the appearance of shranken, fragmented, or condensed cell and nuclear morphologies, and in chromosomal DNA degradation. But, the extract-treated cells did not show DNA fragmentation, which exhibits a nucleosome ladder, suggesting that extract-triggered cell death is not mediated through a typical apoptotic pathway.
Bibliography:2007003579
L74
F60
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0916-8451
1347-6947
DOI:10.1271/bbb.70.1046