Brugada syndrome and job fitness: report of three cases

• Published in: Industrial Health Vol. 61; no. 6; pp. 455 - 461
• Main Authors: CANDURA, Stefano M., VANOLI, Daniela, MAZZANTI, Andrea, D’AMATO, Luca, PRIORI, Silvia G., SCAFA, Fabrizio
• Format: Journal Article
• Language: English
• Published: Japan National Institute of Occupational Safety and Health 01.01.2023; National Institute of Occupational Safety and Health, Japan; National Institute of Occupational Safety and Health, Japan (JNIOSH)
• Subjects: Ajmaline - pharmacology; Apnea; Arrhythmia; Brugada Syndrome - diagnosis; Brugada Syndrome - genetics; Case Report; Complications and side effects; Death, Sudden, Cardiac; EKG; Electrocardiogram; Electrocardiography; Electrocardiography - methods; Electrocardiography, Ambulatory; Electromagnetic fields; Electrophysiological recording; Fainting; Female; Gene mutations; Genetic analysis; Genetic aspects; Health aspects; Heart; Humans; Job stress; Male; Males; Motor vehicle fleets; Mutation; Night shifts; Occupational health; Person-environment fit; Point mutation; Risk; Risk factors; Sleep apnea syndromes; Sleep disorders; Social aspects; Sudden cardiac death; Sudden death; Syncope; Tachyarrhythmia; Tachycardia; Ventricle; Work environment; Work fitness; Italy; Electrocardiography; Work fitness; Arrhythmia; Sudden cardiac death; Syncope; Genetic analysis
• ISSN: 0019-8366; 1880-8026
• DOI: 10.2486/indhealth.2022-0205

Brugada syndrome (BrS) is an inherited arrhythmogenic disorder predisposing patients to a high risk of sudden cardiac death. Specific guidelines on the health surveillance of BrS workers are lacking. We report here three cases requiring assessment of specific job capacity, investigated with an interdisciplinary protocol including 24-h Holter electrocardiography with modified precordial leads, pharmacological test with ajmaline, molecular genetic analysis, electrophysiological study with ventricular stimulation, risk stratification, and occupational medicine evaluation: (1) a female 42-yr-old company manager with positive ajmaline test and CACNA1C gene mutation (judged fit for the job with limitations regarding work-related stress); (2) a male 44-yr-old welder with positive ajmaline test, SCN5A gene mutation, and associated OSAS (obstructive sleep apnea syndrome), who was advised to refrain from night shifts and driving company vehicles; (3) a male 45-yr-old electrical technician with inducible ventricular tachyarrhythmia, who was implanted with a biventricular cardioverter defibrillator, and therefore recommended to avoid exposure to electromagnetic fields and working at heights. We conclude that the collaboration between the cardiologist and the occupational physician allows defining the functional capabilities and the arrhythmogenic risk of BrS workers, to optimize job fitness assessment.