Construction of a Single Component Producer from the Wild Type Avermectin Producer Streptomyces avermitilis

In the present communication, we describe a single component (avermectin B2a) producer derived from Streptomyces avermitilis by two approaches, in vivo and in vitro mutagenesis of the aveC region. Mutagenesis and culture conditions of S. avermitilis were performed as described by us. Mycelial produc...

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Published inJournal of antibiotics Vol. 48; no. 6; pp. 532 - 534
Main Authors IKEDA, HARUO, PANG, CHANG-HONG, ENDO, HIROFUMI, OHTA, TOSHIO, TANAKA, HARUO, OMURA, SATOSHI
Format Journal Article
LanguageEnglish
Published Tokyo JAPAN ANTIBIOTICS RESEARCH ASSOCIATION 1995
Japan Antibiotics Research Association
Subjects
Anthelmintics - isolation & purification
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiparasitic agents
Biological and medical sciences
Chromatography, High Pressure Liquid
Ivermectin - analogs & derivatives
Ivermectin - isolation & purification
Medical sciences
Pharmacology. Drug treatments
Streptomyces - metabolism
Streptomyces avermitilis
Avermectins
Biosynthesis
Mutation
Production
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Summary:In the present communication, we describe a single component (avermectin B2a) producer derived from Streptomyces avermitilis by two approaches, in vivo and in vitro mutagenesis of the aveC region. Mutagenesis and culture conditions of S. avermitilis were performed as described by us. Mycelial products were analyzed by silica gel thin layer chromatography or HPLC as described previously.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-Correspondence-1
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.48.532