Myricetin protects hippocampal CA3 pyramidal neurons and improves learning and memory impairments in rats with Alzheimer’s disease

• Published in: Neural regeneration research Vol. 11; no. 12; pp. 1976 - 1980
• Main Authors: Ramezani, Matin, Darbandi, Niloufar, Khodagholi, Fariba, Hashemi, Azam
• Format: Journal Article
• Language: English
• Published: India Wolters Kluwer India Pvt. Ltd 01.12.2016; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd; Department of Biology, Faculty of Science, Arak University, Arak, Iran; Neuroscience Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran%Department of Biology, Faculty of Science, Arak University, Arak, Iran%Neuroscience Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Medknow Publications & Media Pvt Ltd; Wolters Kluwer Medknow Publications
• Subjects: Alzheimer's disease; Animal cognition; Antioxidants; Brain; Care and treatment; Development and progression; Flavonoids; Health aspects; Laboratory animals; Memory; nerve regeneration; myricetin; Alzheimer′s disease; streptozotocin; hippocampus; pyramidal neurons; CA3 region; behavioral test; neural regeneration; Neural circuitry; Neurogenesis; Neurons; Psychological aspects; Surgery; Variance analysis; Iran; United States > US; Chicago Illinois; behavioral test; myricetin; neural regeneration; hippocampus; streptozotocin; pyramidal neurons; nerve regeneration; CA3 region; Alzheimer's disease
• ISSN: 1673-5374; 1876-7958
• DOI: 10.4103/1673-5374.197141

There is currently no treatment for effectively slowing the progression of Alzheimer’s disease, so early prevention is very important. Numerous studies have shown that flavonoids can improve memory impairment. The present study investigated the effects of myricetin, a member of the flavonoids, on intracerebroventricular streptozotocin induced neuronal loss and memory impairment in rat models of Alzheimer’s disease. Myricetin at 5 or 10 mg/kg was intraperitoneally injected into rats over 21 days. Control rats were treated with 10 m L/kg saline. Behavioral test(the shuttle box test) was performed on day 22 to examine learning and memory in rats. Immediately after that, hematoxylin-eosin staining was performed to observe the morphological change in hippocampal CA3 pyramidal neurons. Myricetin greatly increased the number of hippocampal CA3 pyramidal neurons and improved learning and memory impairments in rats with Alzheimer’s disease. These findings suggest that myricetin is beneficial for treatment of Alzheimer’s disease.