New Plastoquinones Isolated from the Brown Alga, Sargassum micracanthum

Four new plastoquinones were isolated from the methanolic extract of the brown alga, Sargassum micracanthum. Their structures were elucidated based on spectroscopic analysis and chemical conversions from 2-geranylgeranyl-6-methyl-1,4-benzohydroquinone. These plastoquinones exhibited significant anti...

Full description

Saved in:
Bibliographic Details
Published inChemical & Pharmaceutical Bulletin Vol. 53; no. 9; pp. 1159 - 1163
Main Authors Mori, Jun, Iwashima, Makoto, Wakasugi, Hiroko, Saito, Haruo, Matsunaga, Takayuki, Ogasawara, Masaru, Takahashi, Satoshi, Suzuki, Hideyo, Hayashi, Toshimitsu
Format Journal Article
LanguageEnglish
Japanese
Published TOKYO The Pharmaceutical Society of Japan 01.09.2005
Pharmaceutical Society of Japan
Pharmaceutical Soc Japan
Japan Science and Technology Agency
Subjects
Animals
Antineoplastic Agents - pharmacology
antioxidative activity
Biphenyl Compounds - chemistry
Cell Line, Tumor
Cell Proliferation - drug effects
Chemistry
Chemistry, Medicinal
Chemistry, Multidisciplinary
Chloroform
cytotoxic activity
Free Radical Scavengers - chemistry
Free Radical Scavengers - pharmacology
Hydrazines - chemistry
In Vitro Techniques
Life Sciences & Biomedicine
lipid peroxidation
Lipid Peroxidation - drug effects
Liver - drug effects
Liver - metabolism
Magnetic Resonance Spectroscopy
Male
Methanol
Mice
NADP - chemistry
Oxidation-Reduction
Phaeophyceae - chemistry
Pharmacology & Pharmacy
Physical Sciences
Picrates
plastoquinone
Quinones - chemistry
radical scavenger
Rats
Sargassum micracanthum
Science & Technology
Solvents
Spectrometry, Mass, Electrospray Ionization
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet
LIPID-PEROXIDATION
plastoquinone
ANTIOXIDANT
Sargassum micracanthum
radical scavenger
antioxidative activity
cytotoxic activity
lipid peroxidation
Online AccessGet full text

Cover

More Information
Summary:Four new plastoquinones were isolated from the methanolic extract of the brown alga, Sargassum micracanthum. Their structures were elucidated based on spectroscopic analysis and chemical conversions from 2-geranylgeranyl-6-methyl-1,4-benzohydroquinone. These plastoquinones exhibited significant antioxidant activities such as an inhibitory effect on lipid peroxidation and a radical scavenging effect on 1,1-diphenyl-2-picrylhydrazyl (DPPH). Some of the new plastoquiones showed cytotoxic activity against cancer cell line.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.53.1159