SARS-CoV-2: characteristics and current advances in research

• Published in: Virology journal Vol. 17; no. 1; p. 117
• Main Authors: Yang, Yicheng, Xiao, Zhiqiang, Ye, Kaiyan, He, Xiaoen, Sun, Bo, Qin, Zhiran, Yu, Jianghai, Yao, Jinxiu, Wu, Qinghua, Bao, Zhang, Zhao, Wei
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 29.07.2020; BioMed Central; BMC
• Subjects: Amino acids; Angiotensin-Converting Enzyme 2; Antiviral Agents - therapeutic use; Asymptomatic Infections; Betacoronavirus - chemistry; Betacoronavirus - classification; Betacoronavirus - pathogenicity; Betacoronavirus - physiology; Cardiac patients; Cardiovascular disease; Cardiovascular diseases; Comorbidity; Coronaviridae; Coronavirus Infections - drug therapy; Coronavirus Infections - epidemiology; Coronavirus Infections - immunology; Coronavirus Infections - pathology; Coronavirus Infections - therapy; Coronaviruses; COVID-19; COVID-19 infection; Cytokine storm; Disease Susceptibility; Disease transmission; Epidemiology; evolution; Evolution, Molecular; Genome, Viral; Humans; Immunization, Passive; Middle East respiratory syndrome; Mutation; Myocardial injury; Pandemics; pathogenesis; Peptidyl-Dipeptidase A - metabolism; Pneumonia, Viral - epidemiology; Pneumonia, Viral - immunology; Pneumonia, Viral - pathology; Pneumonia, Viral - therapy; Public health; Receptors, Coronavirus; Receptors, Virus - metabolism; Review; SARS Virus - chemistry; SARS Virus - classification; SARS Virus - pathogenicity; SARS Virus - physiology; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; surveys; Thromboembolism; Venous thromboembolism; viral morphology; Viral Proteins - chemistry; virology; Viruses; COVID-19; SARS-CoV-2; Treatment; Cardiovascular disease; Cytokine storm; Venous thromboembolism; Myocardial injury
• ISSN: 1743-422X; 1743-422X
• DOI: 10.1186/s12985-020-01369-z

Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection has spread rapidly across the world and become an international public health emergency. Both SARS-CoV-2 and SARS-CoV belong to subfamily Coronavirinae in the family Coronaviridae of the order Nidovirales and they are classified as the SARS-like species while belong to different cluster. Besides, viral structure, epidemiology characteristics and pathological characteristics are also different. We present a comprehensive survey of the latest coronavirus—SARS-CoV-2—from investigating its origin and evolution alongside SARS-CoV. Meanwhile, pathogenesis, cardiovascular disease in COVID-19 patients, myocardial injury and venous thromboembolism induced by SARS-CoV-2 as well as the treatment methods are summarized in this review.