NR4A1 destabilizes TNF mRNA in microglia and modulates stroke outcomes

• Published in: PLoS biology Vol. 21; no. 7; p. e3002226
• Main Author: Yao, Yao
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 25.07.2023; Public Library of Science (PLoS)
• Subjects: Analysis; Atherosclerosis; Biology and Life Sciences; Brain; Cytokines; Cytoplasm; Disease; Hypotheses; Identification and classification; Inflammation; Ischemia; Medicine and Health Sciences; Messenger RNA; Microglia; Morphology; Primer; Properties; Research and Analysis Methods; Stroke (Disease); Transcription factors; Tumor necrosis factor-TNF; United States

Microglia play a dual role in stroke depending on their pro-inflammatory and anti-inflammatory polarization. A study in PLOS Biology identifies a new mechanism, through which the transcription factor NR4A1 negatively regulates TNF expression in microglia.