NR4A1 destabilizes TNF mRNA in microglia and modulates stroke outcomes

Microglia play a dual role in stroke depending on their pro-inflammatory and anti-inflammatory polarization. A study in PLOS Biology identifies a new mechanism, through which the transcription factor NR4A1 negatively regulates TNF expression in microglia.

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Bibliographic Details
Published inPLoS biology Vol. 21; no. 7; p. e3002226
Main Author Yao, Yao
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 25.07.2023
Public Library of Science (PLoS)
Subjects
Analysis
Atherosclerosis
Biology and Life Sciences
Brain
Cytokines
Cytoplasm
Disease
Hypotheses
Identification and classification
Inflammation
Ischemia
Medicine and Health Sciences
Messenger RNA
Microglia
Morphology
Primer
Properties
Research and Analysis Methods
Stroke (Disease)
Transcription factors
Tumor necrosis factor-TNF
United States
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Summary:Microglia play a dual role in stroke depending on their pro-inflammatory and anti-inflammatory polarization. A study in PLOS Biology identifies a new mechanism, through which the transcription factor NR4A1 negatively regulates TNF expression in microglia.
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The authors have declared that no competing interests exist.
ISSN:1545-7885
1544-9173
1545-7885
DOI:10.1371/journal.pbio.3002226