NR4A1 destabilizes TNF mRNA in microglia and modulates stroke outcomes
Microglia play a dual role in stroke depending on their pro-inflammatory and anti-inflammatory polarization. A study in PLOS Biology identifies a new mechanism, through which the transcription factor NR4A1 negatively regulates TNF expression in microglia.
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| Published in | PLoS biology Vol. 21; no. 7; p. e3002226 |
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| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
United States
Public Library of Science
25.07.2023
Public Library of Science (PLoS) |
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| Online Access | Get full text |
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| Abstract | Microglia play a dual role in stroke depending on their pro-inflammatory and anti-inflammatory polarization. A study in PLOS Biology identifies a new mechanism, through which the transcription factor NR4A1 negatively regulates TNF expression in microglia. |
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| AbstractList | Microglia play a dual role in stroke depending on their pro-inflammatory and anti-inflammatory polarization. A study in
PLOS Biology
identifies a new mechanism, through which the transcription factor NR4A1 negatively regulates TNF expression in microglia.
Microglia play a dual role in stroke depending on their pro-inflammatory and anti-inflammatory polarization. This Primer explores a PLOS Biology study that identifies a new mechanism through which the transcription factor NR4A1 negatively regulates TNF expression in microglia. Microglia play a dual role in stroke depending on their pro-inflammatory and anti-inflammatory polarization. A study in PLOS Biology identifies a new mechanism, through which the transcription factor NR4A1 negatively regulates TNF expression in microglia. Microglia play a dual role in stroke depending on their pro-inflammatory and anti-inflammatory polarization. A study in PLOS Biology identifies a new mechanism, through which the transcription factor NR4A1 negatively regulates TNF expression in microglia.Microglia play a dual role in stroke depending on their pro-inflammatory and anti-inflammatory polarization. A study in PLOS Biology identifies a new mechanism, through which the transcription factor NR4A1 negatively regulates TNF expression in microglia. |
| Audience | Academic |
| Author | Yao, Yao |
| AuthorAffiliation | Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida, United States of America |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/37490433$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1161/CIRCRESAHA.111.253377 10.1016/j.neuroscience.2008.06.052 10.1016/j.celrep.2018.07.065 10.1371/journal.pbio.3002199 10.1016/0166-2236(96)10049-7 10.4049/jimmunol.1600638 10.1016/j.cell.2019.11.010 10.1038/s41593-019-0525-x 10.1161/CIRCRESAHA.111.260760 10.1016/j.pneurobio.2016.01.005 10.1111/jnc.13907 |
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| Copyright | Copyright: © 2023 Yao Yao. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. COPYRIGHT 2023 Public Library of Science 2023 Yao Yao. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2023 Yao Yao 2023 Yao Yao |
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| SubjectTerms | Analysis Atherosclerosis Biology and Life Sciences Brain Cytokines Cytoplasm Disease Hypotheses Identification and classification Inflammation Ischemia Medicine and Health Sciences Messenger RNA Microglia Morphology Primer Properties Research and Analysis Methods Stroke (Disease) Transcription factors Tumor necrosis factor-TNF |
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| Title | NR4A1 destabilizes TNF mRNA in microglia and modulates stroke outcomes |
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